|
Inflammation
|
0.340 |
Biomarker
|
phenotype |
CTD_human |
Salmon and king crab trypsin stimulate interleukin-8 and matrix metalloproteinases via protease-activated receptor-2 in the skin keratinocytic HaCaT cell line.
|
24795235 |
2014 |
|
Inflammation
|
0.340 |
Biomarker
|
phenotype |
LHGDN |
These results suggest that PAR-2 may be involved in allergic nasal inflammation.
|
17727088 |
2007 |
|
Inflammation
|
0.340 |
Biomarker
|
phenotype |
LHGDN |
Thus, trypsin IV and p23 are inhibitor-resistant trypsins that can cleave and activate PARs, causing PAR(1)- and PAR(2)-dependent inflammation and PAR(2)-dependent hyperalgesia.
|
17623652 |
2007 |
|
Inflammation
|
0.340 |
Biomarker
|
phenotype |
LHGDN |
PAR2 has been demonstrated to play a role during inflammation and immune response in different tissues including the skin.
|
16470180 |
2006 |
|
Inflammation
|
0.340 |
Biomarker
|
phenotype |
LHGDN |
Recent knowledge indicates that PAR2 is involved in cutaneous inflammation and immune response.
|
15654951 |
2005 |
|
Inflammation
|
0.340 |
Biomarker
|
phenotype |
CTD_human |
Taken together our data show that both NO and capsaicin-sensitive afferent neurons are involved in PAR-2-mediated colonic inflammation and paracellular permeability increase.
|
12682265 |
2003 |
|
Pruritus
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Induction of leukotriene B(4) and prostaglandin E(2) release from keratinocytes by protease-activated receptor-2-activating peptide in ICR mice.
|
19712758 |
2009 |
|
melanoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Epigenetic silencing of novel tumor suppressors in malignant melanoma.
|
17145863 |
2006 |
|
Myocardial Ischemia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Cardioplegia prevents ischemia-induced transcriptional alterations of cytoprotective genes in rat hearts: a DNA microarray study.
|
16214533 |
2005 |
|
Gastroenteritis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Proteinase-activated receptor-2-induced colonic inflammation in mice: possible involvement of afferent neurons, nitric oxide, and paracellular permeability.
|
12682265 |
2003 |
|
Lung diseases
|
0.220 |
Biomarker
|
group |
BEFREE |
Inhibition of the CatS target, protease-activated receptor 2 (PAR2), in βENaC-Tg mice resulted in a reduction in airway inflammation and mucin expression, indicating a role for this receptor in CatS-induced lung pathology.Our data indicate an important role for CatS in the pathogenesis of CF-like lung disease mediated in part by PAR2 and highlight CatS as a therapeutic target.
|
30655278 |
2019 |
|
Lung diseases
|
0.220 |
Biomarker
|
group |
BEFREE |
Mast cells and the mast cell mediator tryptase may have crucial roles in inducing lung fibroblast migration via PAR-2 activation, which may contribute to remodeling processes in chronic lung diseases.
|
30219079 |
2018 |
|
Lung diseases
|
0.220 |
Biomarker
|
group |
RGD |
Gabexate mesilate inhibits the expression of HMGB1 in lipopolysaccharide-induced acute lung injury.
|
19766246 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, PAR2 deficiency reshaped the tumor microenvironment through accumulation of tumor-promoting myeloid cells including tumor-associated macrophages and myeloid-derived suppressor cells (MDSCs) and reduction of anti-tumor T cells, which established an immunosuppressive microenvironment and facilitated tumor progression.
|
31733286 |
2020 |
|
Tumor Progression
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Moreover, PAR2 deficiency reshaped the tumor microenvironment through accumulation of tumor-promoting myeloid cells including tumor-associated macrophages and myeloid-derived suppressor cells (MDSCs) and reduction of anti-tumor T cells, which established an immunosuppressive microenvironment and facilitated tumor progression.
|
31733286 |
2020 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have previous suggested that PAR-2 and CRTh2 expression on specific peripheral blood cell subtypes may be biomarkers of asthma severity.
|
31168305 |
2019 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Surprisingly, Par2 deficiency had no negative impact on the change of lung function, inflammation and cytokine production in the mouse model of Alt-induced asthma.
|
31430011 |
2019 |
|
Dermatitis, Atopic
|
0.100 |
Biomarker
|
disease |
BEFREE |
We aimed to determine whether the protease-activated receptor 2 over-expressor mouse (PAR2OE) with topical house dust mite (HDM) application is a more comprehensive and clinically representative AD model.
|
31487753 |
2019 |
|
Dermatitis, Atopic
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, β-carotene significantly suppressed protein expression of TNF-α, IL-1β, and MCP-1 and mRNA expression of TSLP, IL-6, IL-1β, IL-4, IL-5, and Par-2 in AD-like skin tissues.
|
31292344 |
2019 |
|
Dermatitis, Atopic
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we tested the ability of a cell-penetrating pepducin, PZ-235, to mitigate the potentially deleterious effects of PAR2 in models of atopic dermatitis.
|
30287285 |
2019 |
|
Dermatitis, Atopic
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Itch, inflammation, and atopic dermatitis are associated with activation of PAR2.
|
30471839 |
2019 |
|
Dermatitis, Atopic
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the skin, PAR2 has extensively documented effects in promoting Th2 inflammation and pruritus; and its role in atopic dermatitis continues to be thoroughly studied.
|
30972831 |
2019 |
|
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
We aimed to determine whether the protease-activated receptor 2 over-expressor mouse (PAR2OE) with topical house dust mite (HDM) application is a more comprehensive and clinically representative AD model.
|
31487753 |
2019 |
|
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, β-carotene significantly suppressed protein expression of TNF-α, IL-1β, and MCP-1 and mRNA expression of TSLP, IL-6, IL-1β, IL-4, IL-5, and Par-2 in AD-like skin tissues.
|
31292344 |
2019 |
|
Eczema
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Itch, inflammation, and atopic dermatitis are associated with activation of PAR2.
|
30471839 |
2019 |