|
Malignant neoplasm of breast
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Here, we aimed to investigate the clinical relevance of TF and TFPI genetic and phenotypic diversity in breast cancer.
|
25882602 |
2015 |
|
Acute Promyelocytic Leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic deletion of the TF cytoplasmic domain, which allows interaction between TF and PAR2, reduced aPL-induced neutrophil activation in aPL-treated mice.
|
18802482 |
2008 |
|
Deep Vein Thrombosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Cannula-associated deep vein thrombosis was found in 75 patients (71.4%) despite it having a mean activated partial thromboplastin time ratio of 1.60 ± 0.31.
|
31770151 |
2019 |
|
Deep Vein Thrombosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Allelic and genotypic frequencies of 5466A>G polymorphism was neither associated with TF levels nor with DVT.
|
29789989 |
2018 |
|
Breast Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Here, we aimed to investigate the clinical relevance of TF and TFPI genetic and phenotypic diversity in breast cancer.
|
25882602 |
2015 |
|
Myocardial Ischemia
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Tissue factor +5466A>G polymorphism determines thrombin formation following vascular injury and thrombin-lowering effects of simvastatin in patients with ischemic heart disease.
|
19027114 |
2009 |
|
Fibrosis, Liver
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Using CCl<sub>4</sub> administration for eight weeks, we induced hepatic fibrosis in wild-type C57BL/6 mice and in mice with deletion of the cytoplasmic signalling domain of TF (TF<sup>§CT/§CT</sup>), deletion of PAR-2 (PAR-2<sup>-/-</sup>) and combined deletion of TF signalling domain and PAR-2 (TF<sup>§CT/§CT</sup>/PAR-2<sup>-/-</sup>).
|
28883694 |
2017 |
|
Myocardial Infarction
|
0.280 |
GeneticVariation
|
disease |
LHGDN |
Admission FVII and TF antigen levels, partially predicted by polymorphisms, are independent predictors of mortality and reinfarction in patients with acute MI.
|
17008590 |
2006 |
|
Myocardial Infarction
|
0.280 |
GeneticVariation
|
disease |
BEFREE |
To investigate whether individual differences in TF gene expression could predispose subjects to thrombosis, we sequenced the 5' domain of the gene up to nucleotide 2732 and found 6 different polymorphisms: 4 of them were completely concordant and defined 2 haplotypes with similar frequencies, designated as 1208 D and 1208 I. Genotyping of patients with myocardial infarction in a case-control study involving 2354 subjects showed no association between the polymorphisms and nonfatal coronary thrombosis.
|
10712418 |
2000 |
|
Myocardial Infarction
|
0.280 |
GeneticVariation
|
disease |
BEFREE |
Because the G allele of the TF promotor polymorphism -603 A/G is associated with monocytic mRNA expression we evaluated its association with myocardial infarction, based on a recessive deleterious effect assumption.
|
15488883 |
2004 |
|
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The objective of this study was to evaluate functionally relevant TF promoter haplotypes as determinants of carotid intima-media thickness (C-IMT), a marker of atherosclerosis.
|
19515372 |
2009 |
|
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The objective of this study was to evaluate functionally relevant TF promoter haplotypes as determinants of carotid intima-media thickness (C-IMT), a marker of atherosclerosis.
|
19515372 |
2009 |
|
Blood Coagulation Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
All surgical patients who are to receive low-dose heparin therapy as a part of such a program should be screened by means of preoperative determination of the partial thromboplastin time, to identify previously unsuspected bleeding disorders.
|
1242430 |
1975 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
430 gliomas from The Cancer Genome Atlas were analyzed for mRNAs associated with coagulation, and 95 gliomas in a tissue microarray were assessed for tissue factor (TF) protein.
|
27664011 |
2016 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Thus, TF could be a useful target for the development of immunotherapeutics for TNBC patients, with or without <i>BRCA1</i> and <i>BRCA2</i> mutations.<i>Cancer </i>.
|
29622581 |
2018 |
|
Cardiovascular Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
To evaluate the relationships of TG influenced by the contact and tissue factor coagulation pathways ex vivo with common single-nucleotide polymorphisms (SNPs) and incident cardiovascular disease and stroke.
|
26286125 |
2015 |
|
Cardiovascular Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A -603A --> G polymorphism (rs1361600) in the promoter region of the TF gene has been associated with serum TF levels and with the development of cardiovascular diseases.
|
20150920 |
2010 |
|
Glioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Previously, we showed that the gene encoding the procoagulant tissue factor (TF), <i>F3</i>, is among the most hypermethylated and downregulated genes in IDH1<sup>mut</sup> gliomas, correlating with greatly reduced thrombosis in patients with IDH1<sup>mut</sup> glioma.
|
30266764 |
2019 |
|
Glioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
430 gliomas from The Cancer Genome Atlas were analyzed for mRNAs associated with coagulation, and 95 gliomas in a tissue microarray were assessed for tissue factor (TF) protein.
|
27664011 |
2016 |
|
Lupus Erythematosus, Systemic
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Three families having more than one affected member with SLE or lupus-like disease were investigated by global coagulation tests as well as methods based on dilute thromboplastin, Russell's viper venom and thermal stability/absorption, and by RIA for anticardiolipin (CL) antibodies.
|
3689698 |
1987 |
|
Lupus Erythematosus, Systemic
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
SLE NETs were decorated with tissue factor (TF) and interleukin-17A (IL-17A), which promoted thrombin generation and the fibrotic potential of cultured skin fibroblasts.
|
30563869 |
2019 |
|
Neoplasm Metastasis
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The procedure involved testing the effect on metastasis of mutations in either the extracellular or cytoplasmic domains of the transmembrane TF molecule.
|
7667269 |
1995 |
|
Polyendocrinopathies, Autoimmune
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Methylation was significantly reduced in the IL8 promoter and significantly increased in the F3 gene body in APS patients compared to HDs and correlated with specific clinical parameters.
|
31103268 |
2019 |
|
Low density lipoprotein cholesterol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
|
Lupus anticoagulant disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The genotype-phenotype analysis showed significant association between the IL-17F rs2397084 and mean value of the hemoglobin (p = 0.01), the IL-17F rs763780 and age (p = 0.008) and lupus anticoagulant (p = 0.09), the IL-23 rs11171806 and urea (p = 0.08) and C3 complement (p = 0.03), and the IL-23R rs1884444 G/T and activated partial thromboplastin time (p = 0.06).
|
27320770 |
2016 |