F3, coagulation factor III, tissue factor, 2152

N. diseases: 456; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0272342
Disease: Familial multiple factor deficiency syndrome, type I
Familial multiple factor deficiency syndrome, type I 		0.010 Biomarker disease BEFREE The main laboratory feature was a prolonged partial thromboplastin time which was corrected by the addition of adsorbed normal plasma but not by the addition of normal serum, hemophilia A plasma or plasma of another patient with combined factor V and factor VIII deficiency. 816163 1976
CUI: C0005779
Disease: Blood Coagulation Disorders
Blood Coagulation Disorders 		0.100 AlteredExpression group BEFREE Coagulation studies in a 50-yr-old French woman without bleeding tendency revealed the following results: whole-blood clotting time in glass tubes and activated partial thromboplastin time with kaolin and ellagic acid were greatly prolonged; one-stage prothrombin was normal; no circulating anticoagulant was detected, and the infusion of normal plasma corrected the coagulation defect with an estimated half-life of 6.5 days; the levels of factor VIII, IX, XI, and XII were normal; mutual correction was obtained with a Fletcher factor-deficient plasma; the level of whole complement was normal. 1174709 1975
CUI: C0005779
Disease: Blood Coagulation Disorders
Blood Coagulation Disorders 		0.100 GeneticVariation group BEFREE All surgical patients who are to receive low-dose heparin therapy as a part of such a program should be screened by means of preoperative determination of the partial thromboplastin time, to identify previously unsuspected bleeding disorders. 1242430 1975
CUI: C0025202
Disease: melanoma
melanoma 		0.100 AlteredExpression disease BEFREE Cell surface expression of functional TF thus contributes to melanoma progression by allowing metastatic cells to provide requisite signals for prolonged adhesive interactions and/or transmigration of tumor cells across the endothelium, resulting in successful metastatic tumor implantation. 1465406 1992
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.100 Biomarker phenotype BEFREE To explore whether TF may contribute to metastatic tumor dissemination, we analyzed the effect of specific inhibition of TF function on human melanoma metastasis in severe combined immunodeficient (SCID) mice. 1465406 1992
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE Using species-specific antibodies to TF, we demonstrate that initial adherence in insufficient for successful tumor cell implantation in a target organ. 1465406 1992
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections 		0.020 AlteredExpression group BEFREE We suggest that the procoagulant state induced by reduction in TM activity and amplified tissue factor activity accompanying HSV infection of endothelium could contribute to deposition of thrombi on atherosclerotic plaques and to the "coagulant-necrosis" state that characterizes HSV-infected mucocutaneous lesions. 2169619 1990
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome 		0.020 AlteredExpression group BEFREE A selective defect in tissue factor mRNA expression in monocytes from AIDS patients. 2293902 1990
CUI: C3854222
Disease: Human immunodeficiency virus (HIV) II infection category B1
Human immunodeficiency virus (HIV) II infection category B1 		0.020 GeneticVariation disease BEFREE Expression of tumor necrosis factor (TNF alpha), tissue factor (TF), and interleukin 1-beta (IL-1 beta) mRNA was evaluated in monocytes isolated from patients infected with human immunodeficiency virus (HIV). 2293902 1990
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.010 AlteredExpression disease BEFREE There was a significant depression (66%) of the induced level of TF mRNA expression in response to lipopolysaccharide. 2293902 1990
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.010 AlteredExpression disease BEFREE There was a significant depression (66%) of the induced level of TF mRNA expression in response to lipopolysaccharide. 2293902 1990
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.010 AlteredExpression phenotype BEFREE There was a significant depression (66%) of the induced level of TF mRNA expression in response to lipopolysaccharide. 2293902 1990
CUI: C0016057
Disease: Fibrosarcoma
Fibrosarcoma 		0.040 Biomarker disease BEFREE A polypeptide factor produced by fibrosarcoma cells that induces endothelial tissue factor and enhances the procoagulant response to tumor necrosis factor/cachectin. 2324115 1990
CUI: C0278595
Disease: Adult Fibrosarcoma
Adult Fibrosarcoma 		0.040 Biomarker disease BEFREE A polypeptide factor produced by fibrosarcoma cells that induces endothelial tissue factor and enhances the procoagulant response to tumor necrosis factor/cachectin. 2324115 1990
CUI: C0004238
Disease: Atrial Fibrillation
Atrial Fibrillation 		0.080 Biomarker disease BEFREE The most prominent mutation hot spot was also the most prominent hot spot for adduct formation as judged by the frequency of termination of in vitro polymerization by the Klenow fragment on N-AcO-TFA-AF-treated plasmids. 2591021 1989
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.040 AlteredExpression disease BEFREE Cells from 10 cases expressed tissue factor mRNA and positive cases were distributed among the myeloblastic, myelomonocytic, and monocytic subtypes of AML. 2617479 1989
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.100 GeneticVariation disease BEFREE Three families having more than one affected member with SLE or lupus-like disease were investigated by global coagulation tests as well as methods based on dilute thromboplastin, Russell's viper venom and thermal stability/absorption, and by RIA for anticardiolipin (CL) antibodies. 3689698 1987
CUI: C0024131
Disease: Lupus Vulgaris
Lupus Vulgaris 		0.030 GeneticVariation disease BEFREE Three families having more than one affected member with SLE or lupus-like disease were investigated by global coagulation tests as well as methods based on dilute thromboplastin, Russell's viper venom and thermal stability/absorption, and by RIA for anticardiolipin (CL) antibodies. 3689698 1987
CUI: C0024138
Disease: Lupus Erythematosus, Discoid
Lupus Erythematosus, Discoid 		0.030 GeneticVariation disease BEFREE Three families having more than one affected member with SLE or lupus-like disease were investigated by global coagulation tests as well as methods based on dilute thromboplastin, Russell's viper venom and thermal stability/absorption, and by RIA for anticardiolipin (CL) antibodies. 3689698 1987
CUI: C0409974
Disease: Lupus Erythematosus
Lupus Erythematosus 		0.030 GeneticVariation disease BEFREE Three families having more than one affected member with SLE or lupus-like disease were investigated by global coagulation tests as well as methods based on dilute thromboplastin, Russell's viper venom and thermal stability/absorption, and by RIA for anticardiolipin (CL) antibodies. 3689698 1987
CUI: C0019069
Disease: Hemophilia A
Hemophilia A 		0.090 Biomarker disease BEFREE In addition they had a prolonged coagulation time with bovine thromboplastin and were therefore cases of hemophilia BM. 3983911 1985
CUI: C0684275
Disease: Hemophilia, NOS
Hemophilia, NOS 		0.070 Biomarker disease BEFREE In addition they had a prolonged coagulation time with bovine thromboplastin and were therefore cases of hemophilia BM. 3983911 1985
CUI: C0015523
Disease: Hereditary Factor XI Deficiency
Hereditary Factor XI Deficiency 		0.030 Biomarker disease BEFREE A black man with a prolonged partial thromboplastin time has a severe deficiency of plasma thromboplastin antecedent (PTA) (factor XI) measured both in clotting assays and immunoassays, suggesting a diagnosis of homozygous PTA deficiency. 7235815 1981
CUI: C0553681
Disease: Hypofibrinogenemia
Hypofibrinogenemia 		0.030 AlteredExpression disease BEFREE Malignant promyelocytes isolated from the patients had increased levels of PCA and TF as compared with the control polymorphonucleates, and low levels of elastase, t-PA, and u-PA; the patient blast PCA level was significantly related to the degree of hypofibrinogenemia. 7579461 1995
CUI: C4316812
Disease: Fibrinogen Deficiency
Fibrinogen Deficiency 		0.020 AlteredExpression disease BEFREE Malignant promyelocytes isolated from the patients had increased levels of PCA and TF as compared with the control polymorphonucleates, and low levels of elastase, t-PA, and u-PA; the patient blast PCA level was significantly related to the degree of hypofibrinogenemia. 7579461 1995