|
Blood Coagulation Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
We hypothesized that the combination of FX and FVIIa could improve thrombin generation (TG) in acquired multifactorial coagulation defects such as seen in cardiac surgery and conducted in vitro evaluation of FVIIa/FX in parallel with other coagulation factor concentrates using in vitro and in vivo diluted plasma samples.
|
30320649 |
2019 |
|
Blood Coagulation Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
A paucity of literature exists regarding the utilization of low molecular weight heparin (LMWH) anti-Xa assays and thromboelastography for identifying coagulopathies associated with oral FXa inhibitors.
|
31375354 |
2019 |
|
Blood Coagulation Disorders
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Bleeding tendency has been moderate in agreement with the extrinsic or intrinsic system assay results-FX level of 4% to 5% is considered normal.
|
28030967 |
2018 |
|
Blood Coagulation Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Congenital factor X (FX) deficiency is a rare bleeding disorder that is inherited as an autosomal recessive trait.
|
30152566 |
2018 |
|
Blood Coagulation Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Factor X (FX) deficiency is a rare autosomal recessive bleeding disorder.
|
29879041 |
2018 |
|
Blood Coagulation Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Less common congenital bleeding disorders include the following deficiencies: Factor I (fibrinogen), Factor II (prothrombin), Factor V, Factor VII, Factor X, Factor XI and Factor XIII, which affect 1953 patients.
|
28335488 |
2017 |
|
Blood Coagulation Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Deficiency of factor X (F10) in humans is a rare bleeding disorder with a heterogeneous phenotype and limited therapeutic options.
|
28576875 |
2017 |
|
Blood Coagulation Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Factor X (FX) deficiency is an autosomal recessive severe bleeding disorder.
|
26708756 |
2016 |
|
Blood Coagulation Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Congenital factor X (FX) deficiency is a rare bleeding disorder inherited as an autosomal recessive trait with an incidence of 1 : 500 000-1 000 000.
|
26222694 |
2015 |
|
Blood Coagulation Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Factor X congenital deficiency is a rare coagulation disorder involving autosomal recessive transmission.
|
26083982 |
2015 |
|
Blood Coagulation Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Combined coagulation factor VII (FVII) and factor X (FX) deficiency (combined FVII/FX deficiency) belongs to the group of bleeding disorders in which both factors show reduced plasma activity.
|
25582404 |
2015 |
|
Blood Coagulation Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
These results suggest that the lower catalytic efficiency of FXa-D185del in the bleeding patient may be partially compensated by the loss of its reactivity with plasma inhibitors, possibly explaining the basis for the paradoxical severe FX deficiency with only mild bleeding tendency for this mutation.
|
25179519 |
2014 |
|
Blood Coagulation Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Factor X (FX) deficiency is a rare autosomal-recessive bleeding disorder caused by diverse mutations in the F10 gene.
|
22931370 |
2013 |
|
Blood Coagulation Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A zymogen-like factor Xa variant corrects the coagulation defect in hemophilia.
|
22020385 |
2011 |
|
Blood Coagulation Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Seventy-nine patients had rare coagulation disorders including deficiency of factor VII (n = 26), factor X (n = 18), factor XIII (n = 9), factor I (n = 9), factor XI (n = 7), factor V (n = 4), combined factor VIII and factor V (n = 4), and combined factor X and factor VII (n = 2).
|
19710607 |
2009 |
|
Blood Coagulation Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Its clinical presentation places FX deficiency among the most severe of the rare coagulation defects, typically including hemarthroses, hematomas, and umbilical cord, gastrointestinal, and central nervous system bleeding.
|
19598069 |
2009 |
|
Blood Coagulation Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Due to a homozygous Gly204Arg mutation in the factor X (FX) gene no detectable FX antigen was found in the plasma of a one-year old patient with severe bleeding diathesis.
|
18245654 |
2008 |
|
Blood Coagulation Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The role of FVIIIa is to markedly increase the catalytic efficiency of factor IXa in the activation of factor X. Variants of these factors frequently also lead to severe bleeding disorders.
|
16487577 |
2007 |
|
Blood Coagulation Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Stuart Prower factor (Factor X) deficiency is a rare hereditary autosomal recessive coagulation disorder.
|
16424563 |
2005 |
|
Blood Coagulation Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
These observations underline the importance of FX function in embryonic and postnatal survival and confirm that these mice serve as effective models of the bleeding disorders observed in human FX deficiency.
|
12161341 |
2002 |
|
Blood Coagulation Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We report two novel mutations in the Factor X gene which result in a bleeding tendency in two unrelated Caucasian families.
|
11246545 |
2001 |
|
Blood Coagulation Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We report a novel mutation in Factor X (FX) gene which results in a phenotype without any bleeding tendency.
|
11728527 |
2001 |
|
Blood Coagulation Disorders
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Platelet prothrombinase activity and microvesicle (MV) generation were measured in four patients from three unrelated families with a life-long bleeding disorder associated with slightly prolonged bleeding time and isolated defective serum prothrombin consumption, without platelet function abnormality or von Willebrand factor defect.
|
9054648 |
1997 |
|
Blood Coagulation Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Factor X Stockton: a mild bleeding diathesis associated with an active site mutation in factor X.
|
8845463 |
1996 |
|
Blood Coagulation Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Thus, the inability of signal peptidase to cleave factor XSanto Domingo is directly responsible for the absence of circulating factor X and leads to the bleeding diathesis in the affected individual.
|
8449937 |
1993 |