FAAH, fatty acid amide hydrolase, 2166

N. diseases: 177; N. variants: 8
Disease: Marijuana Abuse ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024809
Disease: Marijuana Abuse
Marijuana Abuse 		0.380 GeneticVariation disease BEFREE We investigated a potential interaction between genetically inherited variation in fatty acid amide hydrolase (FAAH, C385A), which metabolizes the cannabis-like endocannabinoid anandamide, and dopaminergic system, measured by dopamine receptor levels and mRNA. 31775159 2020
CUI: C0024809
Disease: Marijuana Abuse
Marijuana Abuse 		0.380 Biomarker disease BEFREE <i>Background</i>: Polymorphisms in cannabinoid receptor type 1 (encoded by <i>CNR1</i>) and fatty acid amide hydrolase (encoded by <i>FAAH</i>) have been associated with cannabis dependence, but it remains unknown whether variation within these genes influences cannabis' acute effects on affect. 31184938 2019
CUI: C0024809
Disease: Marijuana Abuse
Marijuana Abuse 		0.380 GeneticVariation disease BEFREE Cannabis group ∗ FAAH genotype interaction predicted WM integrity in bilateral ATR (FA, right: p = .05 and left: p = .001) and fMinor (FA, p = .02). 26106535 2015
CUI: C0024809
Disease: Marijuana Abuse
Marijuana Abuse 		0.380 Biomarker disease PSYGENET These findings support an association with CNR1 and FAAH genes and marijuana-related problems among regular marijuana users. 24172113 2013
CUI: C0024809
Disease: Marijuana Abuse
Marijuana Abuse 		0.380 Biomarker disease BEFREE These findings support an association with CNR1 and FAAH genes and marijuana-related problems among regular marijuana users. 24172113 2013
CUI: C0024809
Disease: Marijuana Abuse
Marijuana Abuse 		0.380 Biomarker disease PSYGENET These findings suggest that, in the absence of FAAH, AEA produces intoxication comparable to THC, and consequently to marijuana. 21300050 2011
CUI: C0024809
Disease: Marijuana Abuse
Marijuana Abuse 		0.380 Biomarker disease PSYGENET These findings are in accord with earlier reported associations between CNR1 and FAAH and CD intermediate phenotypes, and suggest that the underlying mechanism of these genetic effects may be enhanced neural response in reward areas of the brain in carriers of the CNR1 G allele and FAAH C/C genotype in response to marijuana cues. 20010552 2010
CUI: C0024809
Disease: Marijuana Abuse
Marijuana Abuse 		0.380 GeneticVariation disease BEFREE These findings are in accord with earlier reported associations between CNR1 and FAAH and CD intermediate phenotypes, and suggest that the underlying mechanism of these genetic effects may be enhanced neural response in reward areas of the brain in carriers of the CNR1 G allele and FAAH C/C genotype in response to marijuana cues. 20010552 2010
CUI: C0024809
Disease: Marijuana Abuse
Marijuana Abuse 		0.380 GeneticVariation disease BEFREE The SNP, FAAH C385A (rs324420), was examined to determine whether its variance was associated with changes in craving and withdrawal after marijuana abstinence, craving after cue exposure, or sensitivity to the acute effects of marijuana. 19002671 2009
CUI: C0024809
Disease: Marijuana Abuse
Marijuana Abuse 		0.380 GeneticVariation disease BEFREE Two single nucleotide polymorphisms (SNPs) in the CNR1 (rs2023239) and FAAH (rs324420) genes, associated previously with substance abuse and functional changes in cannabinoid regulation, were examined in a sample of daily marijuana smokers. 18705688 2008
CUI: C0024809
Disease: Marijuana Abuse
Marijuana Abuse 		0.380 GeneticVariation disease BEFREE The fatty acid amide hydrolase C385A (P129T) missense variant in cannabis users: studies of drug use and dependence in Caucasians. 17290447 2007