FAAH, fatty acid amide hydrolase, 2166

N. diseases: 177; N. variants: 8
Disease: Enzyme inhibition disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0877008
Disease: Enzyme inhibition disorder
Enzyme inhibition disorder 		0.020 Biomarker phenotype BEFREE Neuroprotective effects of fatty acid amide hydrolase catabolic enzyme inhibition in a HIV-1 Tat model of neuroAIDS. 30114402 2018
CUI: C0877008
Disease: Enzyme inhibition disorder
Enzyme inhibition disorder 		0.020 Biomarker phenotype BEFREE Squirrel monkeys (<i>n</i> = 8) that discriminated the CB<sub>1</sub> full agonist AM4054 (0.01 mg/kg) from vehicle were used to study, first, the inhibitors of fatty acid amide hydrolase (FAAH) or monoacylglycerol lipase (MGL) alone or in combination [FAAH (URB597, AM4303); MGL (AM4301); FAAH/MGL (JZL195, AM4302)] and, second, the ability of the endocannabinoids AEA and 2-AG to produce CB<sub>1</sub> agonist-like effects when administered alone or after enzyme inhibition. 28947487 2017