Esophageal Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
ALDH2*2 heterozygotes have a 7 to 12-fold increased risk for esophageal cancer, a risk increased by drinking alcohol and smoking.
|
31801381 |
2020 |
Esophageal Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
However, the results remain inconclusive.We conducted a comprehensive meta-analysis including 63 articles with 66 studies containing 25,682 cases and 47,455 controls retrieved by searching PubMed and Embase electronic databases up to March 5, 2018.Pooled results indicated that ALDH2 gene rs671 polymorphism was significantly associated with the overall cancer risk in Asians (homozygous model: odds ratio [OR] = 0.85, 95% confidence interval [CI] = 0.72-0.99, P = .042; heterozygous model: OR = 1.32, 95% CI = 1.14-1.52, P < .001; recessive model: OR = 0.73, 95% CI = 0.60-0.88, P = .001; dominant model: OR = 1.32, 95% CI = 1.16-1.51, P < .001; and allele comparison model: OR = 1.11, 95% CI = 1.03-1.19, P = .004), especially in esophageal cancer and among the Chinese and the Japanese.Our results suggest that ALDH2 rs671 polymorphism is associated with the overall cancer risk in Asians.
|
30921184 |
2019 |
Esophageal Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
This study aims to investigate the relationship between ALDH2 rs671 and c12orf30 rs4767364 polymorphisms in the chromosome 12q24 gene, and risk and prognosis of individuals developing esophageal cancer (ESCC) in Xinjiang Kazak and Han populations.
|
28464297 |
2018 |
Esophageal Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
In conclusion, low-activity ALDH2 was associated with increased EC risk among male heavy alcohol consumers.
|
29707772 |
2018 |
Esophageal Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Because of the high prevalence of ALDH2*2 allele among East Asian populations, East Asians may be more susceptible to the carcinogenic effect of alcohol, with most evidence coming from studies of esophageal cancer and head and neck cancer, while data for other cancers are more limited.
|
28253921 |
2017 |
Esophageal Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
It further confirmed that ALDH2 Glu487Lys polymorphism was a high-risk factor for esophageal cancer.
|
28422823 |
2017 |
Esophageal Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
In alcohol drinkers, ALDH2-deficiency is a well-known risk factor for upper aerodigestive tract cancers, i.e., head and neck cancer and esophageal cancer.
|
25831092 |
2015 |
Esophageal Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Our results indicated that the ALDH2 Glu504Lys polymorphism is a susceptible loci associated with overall cancers, especially esophageal cancer and among Japanese population.
|
25680115 |
2015 |
Esophageal Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
ALDH2-deficient individuals have a dramatically elevated risk of esophageal cancer from alcohol consumption.
|
24588059 |
2014 |
Esophageal Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Statistical interaction between ALDH2 (rs671) and alcohol drinking on EC susceptibility in both additive and multiplicative scales was observed.
|
22930414 |
2013 |
Esophageal Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
A strong association between inactive aldehyde dehydrogenase-2 (ALDH2) and risk of esophageal cancer has been demonstrated in East Asian drinkers.
|
22458712 |
2013 |
Esophageal Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Genetic polymorphisms of the alcohol dehydrogenase 1B (ADH1B) and aldehyde dehydrogenase 2 (ALDH2) genes are associated with the risk of esophageal cancer.
|
22703580 |
2012 |
Esophageal Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
The key findings of the earlier studies were that variations (i.e., polymorphisms) in the DNA sequences of the genes encoding alcohol dehydrogenase 1B (i.e., the ADH1B gene), aldehyde dehydrogenase 2 (i.e., the ALDH2 gene), and other alcohol-metabolizing enzymes mediate the risk for alcoholism; moreover, these polymorphisms also have an impact on the risk of alcohol-related cancers, such as esophageal cancer.
|
23134043 |
2012 |
Esophageal Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Our finding showed that ALDH2*1/*2 genotype increases the risk of esophageal cancer, while the ALDH2*2/*2 genotype reduces the risk, presumably preventing people from consumption due to discomfort.
|
22320964 |
2011 |
Esophageal Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
Women with inactive ADH1B and ALDH2 should reduce drinking and increase their intake of vegetable and fruit to prevent development of esophageal cancer.
|
22292652 |
2011 |
Esophageal Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
Inactive heterozygous aldehyde dehydrogenase-2 (ALDH2(*)1/(*)2) and less-active alcohol dehydrogenase-1B (ADH1B(*)1/(*)1) increase the risk of esophageal cancer in East Asian drinkers, and esophageal cancer multiplicity is strongly associated with ALDH2(*)1/(*)2. p53 alterations are key molecular events in multifocal carcinogenesis in the esophagus.
|
21601984 |
2011 |
Esophageal Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
The alleles ALDH2 and MTHFR C677T were critical for determining individual susceptibility to esophageal cancer.
|
21672255 |
2011 |
Esophageal Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
ADH1B/ALDH2 genotypes affect the risk of esophageal cancer, and the risk is modified by alcohol consumption, ethnicity, and gender.
|
20806441 |
2010 |
Esophageal Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Compared with individuals carrying both ALDH2 G/G and ADH2 A/A alleles and with a cumulative amount of alcohol consumption <2.5 (kg * years), drinkers carrying both ALDH2 A and ADH2 G alleles and with a cumulative amount of alcohol consumption > or =2.5 (kg * years) showed a significantly elevated risk of esophageal cancer (OR=53.15, 95% CI: 4.24-666.84).
|
20010786 |
2010 |
Esophageal Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
There were significant correlations between ALDH2 genotypes and alcohol drinking/smoking/history of esophageal cancer.
|
20632450 |
2010 |
Esophageal Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Meta-analysis of ADH1B and ALDH2 polymorphisms and esophageal cancer risk in China.
|
21157980 |
2010 |
Esophageal Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk.
|
19698717 |
2009 |
Esophageal Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
While the distributions of esophageal cancer and ALDH2*504Lys do not precisely correlate, that does not disprove the hypothesis.
|
19456322 |
2009 |
Esophageal Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Both ADH2 G allele and ALDH2 A allele significantly increase the risk of esophageal cancer development in Southeast Chinese males.
|
19452585 |
2009 |
Esophageal Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
ALDH2, MTHFR C677T, CYP1A1 Ile/Val, CYP1A1MspI, CYP2E1, GSTP1, GSTM1 and GSTT1 were examined by meta-analyses and significant relations were found between ALDH2*1*2 and the CYP1A1 Val allele and increased risk of esophageal cancer.
|
17674367 |
2007 |