Flushing
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
The low sensitivity in the present study suggests that a lack of alcohol flushing may play a crucial role in the development of alcohol dependence in women with inactive ALDH2.
|
30629674 |
2019 |
Flushing
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
However, current regular users of alcohol who reported no alcohol flushing may need to undergo genotyping of ALDH2 for a more accurate assessment of the ALDH2 status.
|
30977906 |
2019 |
Flushing
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
CAS is prevalent among East Asians and is associated with an aldehyde dehydrogenase 2 (ALDH2)-deficient genotype (ALDH2*2) and alcohol flushing, which is prevalent among East Asians but is virtually non-existent in other populations.
|
30745502 |
2019 |
Flushing
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Aldehyde dehydrogenase 2 (ALDH2) deficiency causes "Asian flush syndrome," presenting as alcohol-induced facial flushing, tachycardia, nausea, and headaches.
|
31649957 |
2019 |
Flushing
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Aldehyde dehydrogenase 2 deficiency (ALDH2*2) causes facial flushing in response to alcohol consumption in approximately 560 million East Asians.
|
31829281 |
2019 |
Flushing
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Considering that an estimated 560 million East Asians carry a common ALDH2 deficient variant which causes the well-known alcohol flushing syndrome due to acetaldehyde accumulation, the importance of understanding the role of ALDH2 in these diseases should be highlighted.
|
31368097 |
2019 |
Flushing
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
In study set 2, the sensitivity and specificity of the alcohol flushing questionnaire for detecting inactive ALDH2 were 78.9 and 82.1%, respectively.
|
29205834 |
2018 |
Flushing
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
All 3 traits showed genomewide significant association with variants near ALDH2, with significance ranging from 2.01 × 10<sup>-14</sup> (for flushing; lead single nucleotide polymorphism (SNP) PTPN11* rs143894582) to p<sub>meta</sub> = 5.80 × 10<sup>-10</sup> (for alcohol dependence criterion count; lead SNP rs149212747).
|
29460428 |
2018 |
Flushing
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
In conclusion, this study supports a causal effect of alcohol intake on hypertension and indicated that alcohol flushing may be a valid proxy for the ALDH2 rs671 polymorphism, which influences alcohol intake in this Korean population.
|
29323248 |
2018 |
Flushing
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
Some individuals from the Asian population who carry a mutation in the aldehyde dehydrogenase gene (ALDH2*2) cannot metabolize acetaldehyde as efficiently, producing strong effects, including facial flushing, dizziness, hypotension, and palpitations.
|
28578603 |
2017 |
Flushing
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
The ALDH2*2 allele (A-allele) at rs671 is more commonly carried by Asians and is associated with alcohol-related flushing, a strong adverse reaction to alcohol that is protective against drinking.
|
28471244 |
2017 |
Flushing
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
A common polymorphism in ALDH2 gene (ALDH2*2) results in inactivation of the enzyme and is associated with alcohol flushing syndrome and increased risk for cardiovascular and Alzheimer's diseases and some cancers.
|
28431562 |
2017 |
Flushing
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
ALDH2*2 was associated with more subjective flushing symptoms and longer length of flushing but was unrelated to both alcohol frequency and quantity.
|
28728635 |
2017 |
Flushing
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
In terms of precision medicine, ~540 million people in the world have a genetic variant of the aldehyde dehydrogenase 2 (ALDH2) enzyme causing a flushing response and tachycardia after alcohol consumption.
|
27835996 |
2016 |
Flushing
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
The aldehyde dehydrogenase 2 (ALDH2) gene Glu504Lys polymorphism is associated with 'alcohol flush' and might be associated with EH.
|
26691593 |
2016 |
Flushing
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
The Glu504Lys single nucleotide polymorphism (SNP) of ALDH2 gene, which is found in approximately 40% of the East Asian populations, causes defect in the enzyme activity of ALDH2, leading to alterations in acetaldehyde metabolism and alcohol-induced "flushing" syndrome.
|
26491656 |
2015 |
Flushing
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
The prevalence of alcohol flushing syndrome associated with deficient activity of the variant aldehyde dehydrogenase 2 (ALDH2*2) genotype is prevalent among East Asians.
|
25759460 |
2015 |
Flushing
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
Findings indicate that ALDH2*2, rather than ADH1B2*2, is a causal variant allele for the accumulation of blood acetaldehyde and the resultant facial flushing during low alcohol consumption.
|
25365528 |
2014 |
Flushing
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
ALDH2 is strongly associated with flushing response, AD, and maximum drinks in males, with nonsynonymous SNP rs671 explaining 29.2%, 7.9%, and 22.9% of phenotypic variation, respectively, in this sample.
|
24277619 |
2014 |
Flushing
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
Significant gene effects were observed for pulse rate and facial flushing (F-values =62.344; p values <0.001 and F-values =7.062; p values =0.010, respectively, by repeated-measures analysis of variance), which were significantly greater in subjects with the ALDH2*1/*2 genotype.
|
22455355 |
2012 |
Flushing
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
We used a questionnaire inquiring about current and past facial flushing after drinking a glass of beer which identifies the presence of inactive ALDH2 with a sensitivity and specificity of approximately 90%.
|
22234728 |
2012 |
Flushing
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Patients with inactive ALDH2, in whom facial flushing is usually observed after the drinking of alcohol, are at high risk for ESCC as well as multiple UADT cancers.
|
20224884 |
2010 |
Flushing
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
In contrast, in Asians, alcohol-induced asthma and flushing have been shown to be because of a single nucleotide polymorphism (SNP), the acetaldehyde dehydrogenase 2 (ALDH2) 487lys, causing decreased acetaldehyde (the metabolite of ethanol) metabolism and high levels of histamine.
|
20205700 |
2010 |
Flushing
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
We conducted a case-control study to assess the risk of UAT cancer and facial flushing and ALDH2 polymorphism.
|
20518787 |
2010 |
Flushing
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
ALDH2 variation was not associated with flushing or alcohol consumption, but was weakly associated with AD measures.
|
18996923 |
2009 |