FANCA, FA complementation group A, 2175

N. diseases: 211; N. variants: 206
Disease: Solid Neoplasm ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0280100
Disease: Solid Neoplasm
Solid Neoplasm 		0.020 GeneticVariation phenotype BEFREE Our results suggest an older age for cancer development in patients with FANCA mutations and no increased incidence of solid tumors following hematopoietic stem-cell transplant. 31558676 2019
CUI: C0280100
Disease: Solid Neoplasm
Solid Neoplasm 		0.020 GeneticVariation phenotype BEFREE Patients with the other genotypes (FANCA through FANCQ) have cumulative risks of more than 50% of marrow failure, 20% of AML, and 30% of solid tumors (usually head and neck or gynecologic squamous cell carcinoma), by age 40, and they too are at risk of multiple adverse events. 25455269 2015