FANCA, FA complementation group A, 2175

N. diseases: 211; N. variants: 206
Disease: Breast Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.050 GeneticVariation disease BEFREE To the best of our knowledge, the present study is the first to report FANCA gene duplication in patients with breast cancer. 28440412 2017
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.050 GeneticVariation disease BEFREE As only approximately 25% of inherited breast cancers are attributable to BRCA1/2 mutations, FANCA therefore becomes an attractive candidate for breast cancer susceptibility. 23021409 2013
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.050 GeneticVariation disease BEFREE We conclude that FANCA deletions might contribute to breast cancer susceptibility, potentially in combination with other germline mutations. 21236561 2011
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.050 Biomarker disease BEFREE Functional linkage between the FA pathway and genes involved in susceptibility to breast cancer has been demonstrated by the interaction of the FANCA and FANCD2 proteins with BRCA1, and the discovery that the FANCD1 gene is identical to BRCA2. 12915460 2003
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.050 GeneticVariation disease BEFREE Therefore, the FAA gene is not the gene targeted by LOH at 16q24.3 in breast cancer. 10098735 1999