Diabetes Mellitus, Experimental
|
0.200 |
Biomarker
|
disease |
RGD |
Elevated expression of liver X receptor alpha (LXRα) in myocardium of streptozotocin-induced diabetic rats.
|
21136146 |
2011 |
Influenza due to Influenza A virus subtype H1N1
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
No Major Host Genetic Risk Factor Contributed to A(H1N1)2009 Influenza Severity.
|
26379185 |
2015 |
Malignant neoplasm of prostate
|
0.040 |
Biomarker
|
disease |
BEFREE |
Furthermore, we examined the role of ACSL3 in the androgen metabolism of prostate cancer.
|
28771887 |
2017 |
Malignant neoplasm of prostate
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
The data suggest that vitamin D3-repression of FAS mRNA expression is the consequence of feedback inhibition of FAS expression by long chain fatty acyl-CoAs, which are formed by FACL3 during its upregulation by vitamin D3 in human prostate cancer LNCaP cells.
|
15556626 |
2004 |
Malignant neoplasm of prostate
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Moreover, a major target of AR/Oct1 complex, acyl-CoA synthetase 3 (ACSL3), contributes to tumor growth in nude mice, and its high expression is associated with poor prognosis in prostate cancer patients.
|
27270436 |
2016 |
Malignant neoplasm of prostate
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
ENDOD1 and ACSL3 showed down-regulation in high-grade and metastatic PCa, while MCCC2 was overexpressed in low-grade PCa.
|
21829708 |
2011 |
Prostate carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
The data suggest that vitamin D3-repression of FAS mRNA expression is the consequence of feedback inhibition of FAS expression by long chain fatty acyl-CoAs, which are formed by FACL3 during its upregulation by vitamin D3 in human prostate cancer LNCaP cells.
|
15556626 |
2004 |
Prostate carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Furthermore, we examined the role of ACSL3 in the androgen metabolism of prostate cancer.
|
28771887 |
2017 |
Prostate carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Moreover, a major target of AR/Oct1 complex, acyl-CoA synthetase 3 (ACSL3), contributes to tumor growth in nude mice, and its high expression is associated with poor prognosis in prostate cancer patients.
|
27270436 |
2016 |
Prostate carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
ENDOD1 and ACSL3 showed down-regulation in high-grade and metastatic PCa, while MCCC2 was overexpressed in low-grade PCa.
|
21829708 |
2011 |
Asthma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Thus, if validated, methylated ACSL3 5'CGI in UCWBC DNA may be a surrogate endpoint for transplacental PAH exposure and/or a potential biomarker for environmentally-related asthma.
|
19221603 |
2009 |
Asthma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to compare the mRNA expression patterns of Interleukin (IL)-4, interferon (IFN)-γ and Acyl Co A long chain 3 (ACSL3) in peripheral blood leukocytes of children with and without asthma.
|
24450480 |
2014 |
Malignant neoplasm of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
Finally, ACSL3 is essential for mutant KRAS lung cancer tumorigenesis in vivo and is highly expressed in human lung cancer.
|
27477280 |
2016 |
Malignant neoplasm of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Very long-chain acyl-CoA synthetase 3: overexpression and growth dependence in lung cancer.
|
23936004 |
2013 |
Carcinoma of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
Finally, ACSL3 is essential for mutant KRAS lung cancer tumorigenesis in vivo and is highly expressed in human lung cancer.
|
27477280 |
2016 |
Carcinoma of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Very long-chain acyl-CoA synthetase 3: overexpression and growth dependence in lung cancer.
|
23936004 |
2013 |
Primary malignant neoplasm of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
Finally, ACSL3 is essential for mutant KRAS lung cancer tumorigenesis in vivo and is highly expressed in human lung cancer.
|
27477280 |
2016 |
Primary malignant neoplasm of lung
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Very long-chain acyl-CoA synthetase 3: overexpression and growth dependence in lung cancer.
|
23936004 |
2013 |
Hormone refractory prostate cancer
|
0.020 |
Biomarker
|
disease |
BEFREE |
Interestingly, microarray analysis revealed that OCT1 regulates CRPC-specific target genes in addition to representative AR-regulated genes such as ACSL3.
|
30649323 |
2019 |
Hormone refractory prostate cancer
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
CRPC cells showed an increased expression of ACSL3 and an expression pattern of AKR1C3 and UGT2B similar to ACSL3-overexpressing cells.
|
28771887 |
2017 |
Blepharoptosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Saethre-Chotzen syndrome (acrocephalo-syndactyly type III, ACS III) is an autosomal dominant craniosynostosis with brachydactyly, soft tissue syndactyly and facial dysmorphism including ptosis, facial asymmetry and prominent ear crura.
|
8988167 |
1997 |
Craniosynostosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Saethre-Chotzen syndrome (acrocephalo-syndactyly type III, ACS III) is an autosomal dominant craniosynostosis with brachydactyly, soft tissue syndactyly and facial dysmorphism including ptosis, facial asymmetry and prominent ear crura.
|
8988167 |
1997 |
Glioma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The lower fatty acyl pool may be mediated by the lower protein expression levels of long-chain acyl-CoA synthetase 1 (ACSL1), ACSL4, and very long-chain acyl-CoA synthetase 3 (ACSVL3) in IDH1 mutant glioma.
|
30596429 |
2019 |
Hepatitis C
|
0.010 |
Biomarker
|
disease |
LHGDN |
These results identify ACSL3 as a new enzymatic target to limit VLDL secretion and HCV infection.
|
18003621 |
2008 |
Hepatitis C
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results identify ACSL3 as a new enzymatic target to limit VLDL secretion and HCV infection.
|
18003621 |
2008 |