PTK2B, protein tyrosine kinase 2 beta, 2185

N. diseases: 319; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus 		0.500 Biomarker disease CTD_human The onset of SE was accompanied by activation of Src-family tyrosine kinases and Pyk2 in the post-synaptic density, consistent with a role for these enzymes in SE-induced tyrosine phosphorylation. 16600505 2006
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus 		0.500 Biomarker disease RGD The onset of SE was accompanied by activation of Src-family tyrosine kinases and Pyk2 in the post-synaptic density, consistent with a role for these enzymes in SE-induced tyrosine phosphorylation. 16600505 2006
CUI: C0025202
Disease: melanoma
melanoma 		0.340 Biomarker disease BEFREE This review discusses the role MAPK and Phosphatidylinositol-3-kinase-protein kinase B-mammalian target of rapamycin (PI3K-AKT-mTOR) pathways play in the mechanism of resistance of melanomas. 28708099 2017
CUI: C0025202
Disease: melanoma
melanoma 		0.340 Biomarker disease BEFREE We found ERBB4 mutations in 19% of individuals with melanoma and found mutations in two other kinases (FLT1 and PTK2B) in 10% of individuals with melanomas. 19718025 2009
CUI: C0025202
Disease: melanoma
melanoma 		0.340 Biomarker disease CTD_human We found ERBB4 mutations in 19% of individuals with melanoma and found mutations in two other kinases (FLT1 and PTK2B) in 10% of individuals with melanomas. 19718025 2009
CUI: C0025202
Disease: melanoma
melanoma 		0.340 AlteredExpression disease BEFREE Constitutive activation of Akt/protein kinase B in melanoma leads to up-regulation of nuclear factor-kappaB and tumor progression. 12499277 2002
CUI: C0025202
Disease: melanoma
melanoma 		0.340 GeneticVariation disease BEFREE Thus in human melanoma PH domain mutations of PKB/Akt do not play a major role in melanoma carcinogenesis. 11828257 2002
CUI: C0037286
Disease: Skin Neoplasms
Skin Neoplasms 		0.310 Biomarker group CTD_human Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4. 19718025 2009
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.310 Biomarker disease PSYGENET Our results indicate a possible association of alcohol dependence with a genotype of the SNP T137346C of the PTK fyn, with C being the risk allele. 14675807 2003
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.310 GeneticVariation disease BEFREE Our results indicate a possible association of alcohol dependence with a genotype of the SNP T137346C of the PTK fyn, with C being the risk allele. 14675807 2003
CUI: C0037286
Disease: Skin Neoplasms
Skin Neoplasms 		0.310 Biomarker group BEFREE Mutations of the PH domain of protein kinase B (PKB/AKT) are absent in human epidermal skin tumors. 11752813 2001
CUI: C0007114
Disease: Malignant neoplasm of skin
Malignant neoplasm of skin 		0.300 Biomarker disease CTD_human Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4. 19718025 2009
CUI: C0270823
Disease: Petit mal status
Petit mal status 		0.300 Biomarker disease CTD_human Increase in tyrosine phosphorylation of the NMDA receptor following the induction of status epilepticus. 16600505 2006
CUI: C0311335
Disease: Grand Mal Status Epilepticus
Grand Mal Status Epilepticus 		0.300 Biomarker disease CTD_human Increase in tyrosine phosphorylation of the NMDA receptor following the induction of status epilepticus. 16600505 2006
CUI: C0393734
Disease: Complex Partial Status Epilepticus
Complex Partial Status Epilepticus 		0.300 Biomarker disease CTD_human Increase in tyrosine phosphorylation of the NMDA receptor following the induction of status epilepticus. 16600505 2006
CUI: C0751522
Disease: Status Epilepticus, Subclinical
Status Epilepticus, Subclinical 		0.300 Biomarker disease CTD_human Increase in tyrosine phosphorylation of the NMDA receptor following the induction of status epilepticus. 16600505 2006
CUI: C0751523
Disease: Non-Convulsive Status Epilepticus
Non-Convulsive Status Epilepticus 		0.300 Biomarker disease CTD_human Increase in tyrosine phosphorylation of the NMDA receptor following the induction of status epilepticus. 16600505 2006
CUI: C0751524
Disease: Simple Partial Status Epilepticus
Simple Partial Status Epilepticus 		0.300 Biomarker phenotype CTD_human Increase in tyrosine phosphorylation of the NMDA receptor following the induction of status epilepticus. 16600505 2006
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.220 PosttranslationalModification group BEFREE IMD could attenuate the vascular collagen remodeling caused by angiotensin II-induced hypertension via inhibiting phosphorylation of Akt and MAPK. 30229842 2018
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.220 Biomarker group RGD In the present study, we examined whether FAK and PYK2 are up-regulated by elevated blood pressure or circulating humoral factors in hypertension. 21068519 2010
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.220 GeneticVariation group LHGDN To examine the contribution of PTK2B, we sequenced the PTK2B gene using 48 patients with hypertension, identified 62 genetic polymorphisms, and genotyped six representative single nucleotide polymorphisms in population-based case-control samples from 3655 Japanese individuals (1520 patients with hypertension and 2135 controls). 18075463 2007
CUI: C0149721
Disease: Left Ventricular Hypertrophy
Left Ventricular Hypertrophy 		0.210 Biomarker disease BEFREE Transvenous endomyocardial biopsies were obtained in 52 hypertensive patients with left ventricular hypertrophy: 28 without heart failure and 24 with heart failure. gp130 and gp130-dependent antiapoptotic pathways p42/44 mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3 kinase (PI3K)/protein kinase B (Akt) as well as gp130 agonist cardiotrophin-1 were analyzed by reverse transcriptase-polymerase chain reaction and western blot. 17885560 2007
CUI: C0149721
Disease: Left Ventricular Hypertrophy
Left Ventricular Hypertrophy 		0.210 Biomarker disease RGD Furthermore, there was a high degree of correlation (R = 0.75; P < 0.001) between the level of PYK2 and the degree of LVH in 24-wk sham and banded animals. 12124218 2002
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.200 Biomarker disease BEFREE Alzheimer's Disease Risk Factor Pyk2 Mediates Amyloid-β-Induced Synaptic Dysfunction and Loss. 30518596 2019
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.200 GeneticVariation disease GWASCAT Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk. 30617256 2019