FANCF, FA complementation group F, 2188

N. diseases: 153; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3469526
Disease: FANCONI ANEMIA, COMPLEMENTATION GROUP F
FANCONI ANEMIA, COMPLEMENTATION GROUP F 		0.620 PosttranslationalModification disease BEFREE To assess the 5' CpG island methylation of Fanconi anemia, complementation group F (FANCF) gene in epithelial ovarian cancer (EOC) tissues and normal ovarian tissues and to investigate the relationship between FANCF methylation and clinicopathologic features and prognosis of EOC. 26507869 2016
CUI: C3469526
Disease: FANCONI ANEMIA, COMPLEMENTATION GROUP F
FANCONI ANEMIA, COMPLEMENTATION GROUP F 		0.620 CausalMutation disease CLINVAR Clinical aspects of Fanconi anemia individuals with the same mutation of FANCF identified by next generation sequencing. 26033879 2015
CUI: C3469526
Disease: FANCONI ANEMIA, COMPLEMENTATION GROUP F
FANCONI ANEMIA, COMPLEMENTATION GROUP F 		0.620 Biomarker disease BEFREE Fanconi anemia complementation group-F (FANCF) is a key factor to maintain the function of FA/BRCA, a DNA-damage response pathway. 22952942 2012
CUI: C3469526
Disease: FANCONI ANEMIA, COMPLEMENTATION GROUP F
FANCONI ANEMIA, COMPLEMENTATION GROUP F 		0.620 Biomarker disease GENOMICS_ENGLAND How the fanconi anemia pathway guards the genome. 19686080 2009
CUI: C3469526
Disease: FANCONI ANEMIA, COMPLEMENTATION GROUP F
FANCONI ANEMIA, COMPLEMENTATION GROUP F 		0.620 GeneticVariation disease CLINVAR A rapid method for retrovirus-mediated identification of complementation groups in Fanconi anemia patients. 16084127 2005
CUI: C3469526
Disease: FANCONI ANEMIA, COMPLEMENTATION GROUP F
FANCONI ANEMIA, COMPLEMENTATION GROUP F 		0.620 CausalMutation disease CLINVAR A rapid method for retrovirus-mediated identification of complementation groups in Fanconi anemia patients. 16084127 2005
CUI: C3469526
Disease: FANCONI ANEMIA, COMPLEMENTATION GROUP F
FANCONI ANEMIA, COMPLEMENTATION GROUP F 		0.620 CausalMutation disease CLINVAR The Fanconi anaemia gene FANCF encodes a novel protein with homology to ROM. 10615118 2000
CUI: C3469526
Disease: FANCONI ANEMIA, COMPLEMENTATION GROUP F
FANCONI ANEMIA, COMPLEMENTATION GROUP F 		0.620 Biomarker disease GENOMICS_ENGLAND The Fanconi anaemia gene FANCF encodes a novel protein with homology to ROM. 10615118 2000
CUI: C3469526
Disease: FANCONI ANEMIA, COMPLEMENTATION GROUP F
FANCONI ANEMIA, COMPLEMENTATION GROUP F 		0.620 GeneticVariation disease CLINVAR The Fanconi anaemia gene FANCF encodes a novel protein with homology to ROM. 10615118 2000
CUI: C3469526
Disease: FANCONI ANEMIA, COMPLEMENTATION GROUP F
FANCONI ANEMIA, COMPLEMENTATION GROUP F 		0.620 Biomarker disease GENOMICS_ENGLAND Evidence for at least eight Fanconi anemia genes. 9382107 1997
CUI: C3469526
Disease: FANCONI ANEMIA, COMPLEMENTATION GROUP F
FANCONI ANEMIA, COMPLEMENTATION GROUP F 		0.620 Biomarker disease CTD_human
CUI: C3469526
Disease: FANCONI ANEMIA, COMPLEMENTATION GROUP F
FANCONI ANEMIA, COMPLEMENTATION GROUP F 		0.620 Biomarker disease GENOMICS_ENGLAND
CUI: C0023418
Disease: leukemia
leukemia 		0.510 Biomarker disease GENOMICS_ENGLAND Germline Genetic Predisposition to Hematologic Malignancy. 28297620 2017
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.510 Biomarker disease GENOMICS_ENGLAND Germline Genetic Predisposition to Hematologic Malignancy. 28297620 2017
CUI: C0023418
Disease: leukemia
leukemia 		0.510 Biomarker disease BEFREE Involvement of Fanconi anemia genes FANCD2 and FANCF in the molecular basis of drug resistance in leukemia. 25647473 2015
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.510 Biomarker disease BEFREE Bi-allelic silencing of the Fanconi anaemia gene FANCF in acute myeloid leukaemia. 14617007 2003
CUI: C0023418
Disease: leukemia
leukemia 		0.510 CausalMutation disease CGI
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.510 CausalMutation disease CGI
CUI: C0015625
Disease: Fanconi Anemia
Fanconi Anemia 		0.500 GeneticVariation disease BEFREE It is the first report of a mutation in the FANCF gene in Iranian patients with Fanconi anemia. 31288759 2019
CUI: C0015625
Disease: Fanconi Anemia
Fanconi Anemia 		0.500 GeneticVariation disease BEFREE Many had mutations in Fanconi anemia complex genes [BRCA2 (3 participants), FANCF, FANCM]. 28687971 2018
CUI: C0015625
Disease: Fanconi Anemia
Fanconi Anemia 		0.500 GeneticVariation disease BEFREE Currently, information on the phenotypic findings of patients with Fanconi anemia from biallelic mutations in FANCF is limited. 27714961 2017
CUI: C0015625
Disease: Fanconi Anemia
Fanconi Anemia 		0.500 Biomarker disease BEFREE The Fanconi anemia (FA)‑associated proteins FANCF and FANCD2 are important components of the FA pathway of DNA crosslink repair. 25647473 2015
CUI: C0015625
Disease: Fanconi Anemia
Fanconi Anemia 		0.500 GeneticVariation disease BEFREE Clinical aspects of Fanconi anemia individuals with the same mutation of FANCF identified by next generation sequencing. 26033879 2015
CUI: C0015625
Disease: Fanconi Anemia
Fanconi Anemia 		0.500 Biomarker disease BEFREE We found that silencing of FANCF inactivated the FA/BRCA pathway by decreasing the monoubiquitination and focus formation of FANCD2 and reduced the function of the FA/BRCA pathway, resulting in the inhibition of cell proliferation, increased cell apoptosis and DNA damage in OVCAR3 cells. 23440494 2013
CUI: C0015625
Disease: Fanconi Anemia
Fanconi Anemia 		0.500 Biomarker disease BEFREE Six small molecules, including bortezomib (proteasome inhibitor), CA-074-Me (cathepsin B inhibitor) and 17-AAG (HSP90 inhibitor), synergized with cisplatin specifically in FA-proficient ovarian cancer cells (2008 + FANCF), but not in FA-deficient isogenic cells (2008). 22537224 2012