|
Synpolydactyly 2
|
0.600 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Mutation of fibulin-1 causes a novel syndrome involving the central nervous system and connective tissues.
|
24084572 |
2014 |
|
Synpolydactyly 2
|
0.600 |
GermlineCausalMutation
|
disease |
ORPHANET |
The epidemiology, genetics and future management of syndactyly.
|
22448207 |
2012 |
|
Synpolydactyly 2
|
0.600 |
GermlineCausalMutation
|
disease |
ORPHANET |
The fibulin-1 gene (FBLN1) is disrupted in a t(12;22) associated with a complex type of synpolydactyly.
|
11836357 |
2002 |
|
Synpolydactyly 2
|
0.600 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
Synpolydactyly 2
|
0.600 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Malignant neoplasm of prostate
|
0.320 |
Biomarker
|
disease |
BEFREE |
Our data indicate that Fibulin-1 functions as a HS-5 bone marrow stromal cell-derived factor inducing prostate cancer cell death.Prostate 77:729-742, 2017.
|
28168724 |
2017 |
|
Malignant neoplasm of prostate
|
0.320 |
Biomarker
|
disease |
CTD_human |
Our recent microarray analysis suggested downregulation of three fibulins, FBLN1, FBLN4, and FBLN5, in prostate cancer, while two further ECM genes, SPOCK1 (testican) and TENC (tenascin C), appeared upregulated or unchanged.
|
17929269 |
2007 |
|
Malignant neoplasm of prostate
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
Real-time RT-PCR revealed GADD45A, MX1, EPB41L3/DAL1, and FBLN1 as generally downregulated in prostate cancer, whereas HOXB13 and EPB41L4B were upregulated.
|
17280610 |
2007 |
|
Endometriosis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Unique transcriptome, pathways, and networks in the human endometrial fibroblast response to progesterone in endometriosis.
|
20864642 |
2011 |
|
Endometrioma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Unique transcriptome, pathways, and networks in the human endometrial fibroblast response to progesterone in endometriosis.
|
20864642 |
2011 |
|
Prostatic Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Downregulation of several fibulin genes in prostate cancer.
|
17929269 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The aim of this work is to evaluate Fibulin-1 (FBLN1) and serine threonine kinase-31 (STK31) as colorectal cancer (CRC) tumour markers and their ability to differentiate it from colorectal benign lesions.
|
29715435 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Fibulin-1 interacts with SHBG, it is associated with a less aggressive behavior of breast cancer cells and correlates to a better prognosis of the tumor.
|
29940241 |
2018 |
|
Red Blood Cell Count measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
When investigating the correlation between fibulin-1 expression and clinicopathological characteristics, we have found that low fibulin-1 protein expression was associated with poor tumor differentiation and advanced N stage.
|
26779638 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results indicated that the FBLN1 gene may be a novel candidate of tumor suppressor gene in CRC, and that promoter hypermethylation of FBLN1 is an important reason for its downregulation and is also a good predictor of OS for CRC.
|
25837757 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In conclusion, our results indicated that FBLN1 is a novel candidate of tumor suppressor gene and that promoter hypermethylation of FBLN1 is associated with tumor progression in CM.
|
23907575 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Altogether, our results indicated that fibulin-1 expression is associated with NMIBC grade and recurrence, it is epigenetically down-regulated and functions as a tumor suppressor gene and angiogenesis inhibitor in bladder cancer.
|
25234557 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Fibulin-1 over expression led dramatically to decreased cell growth, enhanced tumor cell apoptosis, decreased cell motility and angiogenesis in cultured renal cell carcinoma cells and in xenograft tumors in nude mice.
|
23391467 |
2013 |
|
Bipolar Disorder
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study of temperament in bipolar disorder reveals significant associations with three novel Loci.
|
22365631 |
2012 |
|
Bipolar Disorder
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of temperament in bipolar disorder reveals significant associations with three novel Loci.
|
22365631 |
2012 |
|
Personality Traits
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Genome-wide association study of temperament in bipolar disorder reveals significant associations with three novel Loci.
|
22365631 |
2012 |
|
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Moreover, promoter hypermethylation of FBLN1 was significantly associated with advanced stage HCC, multiple tumors and increased tumor size.
|
21268132 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
CD31 labeling and TUNEL assay further reveal that fibulin-1 suppression of HT1080 tumor growth is associated with diminished angiogenesis and also enhanced apoptosis of endothelial cells and tumor cells.
|
18222970 |
2008 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Doxorubicin was also found to augment tumor expression of the fibulin-1-binding proteins fibronectin and laminin-1.
|
17483339 |
2007 |