CCNY, cyclin Y, 219771

N. diseases: 26; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.430 GeneticVariation disease BEFREE Colon-only CD (n = 228) was compared with healthy controls: three of six UC SNPs (in MST1, HLA-DRA, and IL-23R) and 11 of 34 CD SNPs: in IRGM, NOD2 (rs2066845), CCNY, MST1, IL23R, PTPN22, C11orf30, ZNF365, PTPN2, PSMG1, and rs1456893 were significantly associated. 21830272 2011
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.430 GeneticVariation disease BEFREE We identified multiple previously unreported or unconfirmed disease associations, including known CD loci (ICOSLG and TNFSF15) and T1D loci (TNFAIP3) that confer UC risk, known UC loci (HERC2 and IL26) that confer T1D risk and known UC loci (IL10 and CCNY) that confer CD risk. 20176734 2010
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.430 GeneticVariation disease GWASDB Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. 18587394 2008
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.430 GeneticVariation disease LHGDN Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. 18438405 2008
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.430 Biomarker disease CTD_human Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. 18438405 2008
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.420 GeneticVariation disease GWASCAT Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. 21297633 2011
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.420 GeneticVariation disease GWASDB Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. 21297633 2011
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.420 GeneticVariation disease BEFREE We identified multiple previously unreported or unconfirmed disease associations, including known CD loci (ICOSLG and TNFSF15) and T1D loci (TNFAIP3) that confer UC risk, known UC loci (HERC2 and IL26) that confer T1D risk and known UC loci (IL10 and CCNY) that confer CD risk. 20176734 2010
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.420 GeneticVariation disease BEFREE Among these loci, we identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated only with ulcerative colitis in our sample collection. 18438405 2008
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.420 Biomarker disease CTD_human Among these loci, we identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated only with ulcerative colitis in our sample collection. 18438405 2008
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.420 GeneticVariation disease LHGDN Among these loci, we identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated only with ulcerative colitis in our sample collection. 18438405 2008
CUI: C0156147
Disease: Crohn's disease of large bowel
Crohn's disease of large bowel 		0.300 Biomarker disease CTD_human Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. 18438405 2008
CUI: C0267380
Disease: Crohn's disease of the ileum
Crohn's disease of the ileum 		0.300 Biomarker disease CTD_human Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. 18438405 2008
CUI: C0678202
Disease: Regional enteritis
Regional enteritis 		0.300 Biomarker disease CTD_human Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. 18438405 2008
CUI: C0949272
Disease: IIeocolitis
IIeocolitis 		0.300 Biomarker disease CTD_human Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. 18438405 2008
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.040 AlteredExpression phenotype BEFREE With further analysis of the CCNY levels, there were no differences in age, sex, smoking status, tumor location, histologic subtype, or tumor size, but differences were observed in lymphatic (<i>P</i><0.001) and distant (<i>P</i><0.001) metastases in NSCLC patients. 30774378 2019
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.040 Biomarker disease BEFREE CCNY, a novel cyclin family member, plays an increasingly important role in the progression of tumor invasion and metastasis, including lung cancer. 30774378 2019
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.040 Biomarker phenotype BEFREE Cyclin Y Modulates the Proliferation, Invasion, and Metastasis of Hepatocellular Carcinoma Cells. 29557391 2018
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.040 Biomarker phenotype BEFREE We also identified recurrent focal amplification of gene CCNY derived from BFB in two metastatic tumors, but not in primary tumor. 28381877 2017
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.040 Biomarker phenotype BEFREE Moreover, in a Cox regression analysis, anti-CCNY autoantibody was an independent factor that predicted poor prognosis for postoperative patients with early-stage NSCLC (P = 0.026) as well as for those with distant metastasis (P = 0.012). 24167380 2013
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.040 Biomarker disease BEFREE Serum anti-CCNY autoantibody is an independent prognosis indicator for postoperative patients with early-stage nonsmall-cell lung carcinoma. 24167380 2013
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.040 Biomarker disease BEFREE Hence, the aim of this study was to explore the potential role of CCNY in lung cancer. 21273179 2011
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.040 AlteredExpression disease BEFREE The expression status of CCNY in lung cancer and its clinical significance remain unknown. 20596919 2010
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.030 Biomarker group BEFREE We identified several candidates implicating the CDK16/CCNY complex in cytoskeletal dynamics, and we focused on the microtubule-associated protein regulator of cytokinesis (PRC1), an essential protein for cell division that organizes antiparallel microtubules and whose deregulation may drive genomic instability in cancer. 30992425 2019
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.030 Biomarker disease BEFREE In the training set, serum CCNY was markedly increased in the NSCLC patients (<i>P</i><0.05) with an integrated area under the curve of 0.751. 30774378 2019