FCAR, Fc fragment of IgA receptor, 2204

N. diseases: 38; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis 		0.090 AlteredExpression disease BEFREE IgA nephropathy-specific expression of the IgA Fc receptors (CD89) on blood phagocytic cells. 9367406 1997
CUI: C3161650
Disease: Primary immunoglobulin A nephropathy (disorder)
Primary immunoglobulin A nephropathy (disorder) 		0.010 Biomarker disease BEFREE Finally, the binding of aIgA2 to CD89 was less inhibited using mIgA from patients with IgAN compared to controls. 9870466 1998
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis 		0.090 Biomarker disease BEFREE Fcalpha receptor (CD89) mediates the development of immunoglobulin A (IgA) nephropathy (Berger's disease). Evidence for pathogenic soluble receptor-Iga complexes in patients and CD89 transgenic mice. 10839814 2000
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis 		0.090 GeneticVariation disease BEFREE Genetic polymorphisms in the promoter and 5' UTR region of the Fc alpha receptor (CD89) are not associated with a risk of IgA nephropathy. 11776381 2001
CUI: C0268731
Disease: Renal glomerular disease
Renal glomerular disease 		0.010 GeneticVariation group BEFREE We screened genomic DNA samples from patients with IgAN and those with other glomerular diseases for polymorphisms in the promoter and the 5'-untranslated region region of the FcalphaR gene by direct nucleotide sequencing. 11776381 2001
CUI: C0744471
Disease: Gram-negative bacteremia
Gram-negative bacteremia 		0.010 AlteredExpression disease BEFREE Enhanced expression of Fc alpha receptor I on blood phagocytes of patients with gram-negative bacteremia is associated with tyrosine phosphorylation of the FcR-gamma subunit. 11699071 2001
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.030 Biomarker group BEFREE Previous studies have demonstrated that, in addition to IgG Fc receptors, the human myeloid IgA receptor (Fc(alpha)RI, CD89) also effectively triggered tumor cell killing. 12393717 2002
CUI: C0005283
Disease: beta Thalassemia
beta Thalassemia 		0.010 Biomarker disease BEFREE Otherwise, Hb Korea, CDs 89/90 -GT and a novel beta-thalassemia mutation, CD 131 CAG-->TAG, were only identified in Koreans. 12430907 2002
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.010 Biomarker group BEFREE Binding, internalization, and catabolic degradation of myeloma IgA1 protein as a standard control and the isolated CIC were studied using human MC, hepatoma cell line HepG2 expressing the asialoglycoprotein receptor (ASGP-R), and monocyte-like cell line U937 expressing the Fc(alpha)-R (CD89). 12110007 2002
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.010 Biomarker disease BEFREE Binding, internalization, and catabolic degradation of myeloma IgA1 protein as a standard control and the isolated CIC were studied using human MC, hepatoma cell line HepG2 expressing the asialoglycoprotein receptor (ASGP-R), and monocyte-like cell line U937 expressing the Fc(alpha)-R (CD89). 12110007 2002
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.010 Biomarker disease BEFREE Binding, internalization, and catabolic degradation of myeloma IgA1 protein as a standard control and the isolated CIC were studied using human MC, hepatoma cell line HepG2 expressing the asialoglycoprotein receptor (ASGP-R), and monocyte-like cell line U937 expressing the Fc(alpha)-R (CD89). 12110007 2002
CUI: C3841475
Disease: beta^+^ Thalassemia
beta^+^ Thalassemia 		0.010 Biomarker disease BEFREE Otherwise, Hb Korea, CDs 89/90 -GT and a novel beta-thalassemia mutation, CD 131 CAG-->TAG, were only identified in Koreans. 12430907 2002
CUI: C0001342
Disease: Acute periodontitis
Acute periodontitis 		0.010 GeneticVariation disease BEFREE A novel polymorphism of FcalphaRI (CD89) associated with aggressive periodontitis. 15140034 2004
CUI: C0031106
Disease: Aggressive Periodontitis
Aggressive Periodontitis 		0.010 GeneticVariation disease BEFREE A novel polymorphism of FcalphaRI (CD89) associated with aggressive periodontitis. 15140034 2004
CUI: C0155877
Disease: Allergic asthma
Allergic asthma 		0.010 GeneticVariation disease BEFREE Nevertheless, this is the first report on the distribution of 6 single nucleotide polymorphisms of the FCAR gene in a human population and the first study on FCAR polymorphism in allergic asthma. 15564774 2004
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.010 GeneticVariation disease LHGDN Asp92Asn polymorphism in the myeloid IgA Fc receptor is associated with myocardial infarction in two disparate populations: CARE and WOSCOPS. 17008591 2006
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.010 Biomarker disease BEFREE These results suggest that the FCAR promoter SNPs may be related to chronic HCV infection and disease progression in Japanese CHC, which might be explained by altered FcalphaR expression affecting IgA-mediated immune responses and/or IgA catabolism. 17033823 2006
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.010 GeneticVariation disease LHGDN Because the myeloid IgA Fc receptor encoded by FCAR mediates inflammation, we hypothesized that the FCAR Asp92Asn polymorphism is associated with risk of MI and that this risk would be modified by pravastatin. 17008591 2006
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.010 GeneticVariation disease BEFREE Because the myeloid IgA Fc receptor encoded by FCAR mediates inflammation, we hypothesized that the FCAR Asp92Asn polymorphism is associated with risk of MI and that this risk would be modified by pravastatin. 17008591 2006
CUI: C0524910
Disease: Hepatitis C, Chronic
Hepatitis C, Chronic 		0.010 GeneticVariation disease BEFREE Genetic variants of the IgA Fc receptor (FcalphaR, CD89) promoter in chronic hepatitis C patients. 17033823 2006
CUI: C0524910
Disease: Hepatitis C, Chronic
Hepatitis C, Chronic 		0.010 Biomarker disease LHGDN Genetic variants of the IgA Fc receptor (FcalphaR, CD89) promoter in chronic hepatitis C patients. 17033823 2006
CUI: C1861453
Disease: Pseudohyperkalemia Cardiff
Pseudohyperkalemia Cardiff 		0.010 Biomarker disease BEFREE These results suggest that the FCAR promoter SNPs may be related to chronic HCV infection and disease progression in Japanese CHC, which might be explained by altered FcalphaR expression affecting IgA-mediated immune responses and/or IgA catabolism. 17033823 2006
CUI: C3714514
Disease: Infection
Infection 		0.010 Biomarker group LHGDN Genetic variants of the IgA Fc receptor (FcalphaR, CD89) promoter in chronic hepatitis C patients. 17033823 2006
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis 		0.030 AlteredExpression disease BEFREE Fc alpha receptor I activation induces leukocyte recruitment and promotes aggravation of glomerulonephritis through the FcR gamma adaptor. 17393381 2007
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.030 Biomarker group BEFREE Anti-FcalphaRI Fab treatment of nude mice injected subcutaneously with FcalphaRI+ mast-cell transfectants prevented tumor development and halted the growth of established tumors. 16990604 2007