|
IGA Glomerulonephritis
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
IgA nephropathy-specific expression of the IgA Fc receptors (CD89) on blood phagocytic cells.
|
9367406 |
1997 |
|
Glomerulonephritis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Fc alpha receptor I activation induces leukocyte recruitment and promotes aggravation of glomerulonephritis through the FcR gamma adaptor.
|
17393381 |
2007 |
|
Acute periodontitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A novel polymorphism of FcalphaRI (CD89) associated with aggressive periodontitis.
|
15140034 |
2004 |
|
Aggressive Periodontitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A novel polymorphism of FcalphaRI (CD89) associated with aggressive periodontitis.
|
15140034 |
2004 |
|
Dermatitis Herpetiformis
|
0.010 |
Biomarker
|
disease |
BEFREE |
A positive correlation was revealed between CD89 immunoexpression and anti-npG IgA in DH.
|
29417981 |
2017 |
|
Nephritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Although the molecular features of human IgA1 are different from rodent IgA, human IgA1 knock-in (α1KI)-CD89 transgenic mice, which express both human IgA1 and CD89, show circulating and mesangial deposits of IgA1-soluble CD89 complexes that result in kidney inflammation, hematuria, and proteinuria.
|
30177023 |
2018 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Anti-FcalphaRI Fab treatment of nude mice injected subcutaneously with FcalphaRI+ mast-cell transfectants prevented tumor development and halted the growth of established tumors.
|
16990604 |
2007 |
|
Ulcerative Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
As such, we investigated whether IgA-Fc(alpha)RI interaction contributes to tissue damage in UC.
|
19555692 |
2009 |
|
Coronary heart disease
|
0.010 |
GeneticVariation
|
disease |
LHGDN |
Asp92Asn polymorphism in the myeloid IgA Fc receptor is associated with myocardial infarction in two disparate populations: CARE and WOSCOPS.
|
17008591 |
2006 |
|
Myocardial Infarction
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Because the myeloid IgA Fc receptor encoded by FCAR mediates inflammation, we hypothesized that the FCAR Asp92Asn polymorphism is associated with risk of MI and that this risk would be modified by pravastatin.
|
17008591 |
2006 |
|
Myocardial Infarction
|
0.010 |
GeneticVariation
|
disease |
LHGDN |
Because the myeloid IgA Fc receptor encoded by FCAR mediates inflammation, we hypothesized that the FCAR Asp92Asn polymorphism is associated with risk of MI and that this risk would be modified by pravastatin.
|
17008591 |
2006 |
|
Multiple Myeloma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Binding, internalization, and catabolic degradation of myeloma IgA1 protein as a standard control and the isolated CIC were studied using human MC, hepatoma cell line HepG2 expressing the asialoglycoprotein receptor (ASGP-R), and monocyte-like cell line U937 expressing the Fc(alpha)-R (CD89).
|
12110007 |
2002 |
|
Liver neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Binding, internalization, and catabolic degradation of myeloma IgA1 protein as a standard control and the isolated CIC were studied using human MC, hepatoma cell line HepG2 expressing the asialoglycoprotein receptor (ASGP-R), and monocyte-like cell line U937 expressing the Fc(alpha)-R (CD89).
|
12110007 |
2002 |
|
Liver carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Binding, internalization, and catabolic degradation of myeloma IgA1 protein as a standard control and the isolated CIC were studied using human MC, hepatoma cell line HepG2 expressing the asialoglycoprotein receptor (ASGP-R), and monocyte-like cell line U937 expressing the Fc(alpha)-R (CD89).
|
12110007 |
2002 |
|
IGA Glomerulonephritis
|
0.090 |
Biomarker
|
disease |
BEFREE |
Circulating CD89-IgA complex does not predict deterioration of kidney function in Korean patients with IgA nephropathy.
|
28672768 |
2017 |
|
Gram-negative bacteremia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Enhanced expression of Fc alpha receptor I on blood phagocytes of patients with gram-negative bacteremia is associated with tyrosine phosphorylation of the FcR-gamma subunit.
|
11699071 |
2001 |
|
IGA Glomerulonephritis
|
0.090 |
Biomarker
|
disease |
BEFREE |
Fcalpha receptor (CD89) mediates the development of immunoglobulin A (IgA) nephropathy (Berger's disease). Evidence for pathogenic soluble receptor-Iga complexes in patients and CD89 transgenic mice.
|
10839814 |
2000 |
|
Primary immunoglobulin A nephropathy (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
Finally, the binding of aIgA2 to CD89 was less inhibited using mIgA from patients with IgAN compared to controls.
|
9870466 |
1998 |
|
IGA Glomerulonephritis
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphisms in the promoter and 5' UTR region of the Fc alpha receptor (CD89) are not associated with a risk of IgA nephropathy.
|
11776381 |
2001 |
|
Hepatitis C, Chronic
|
0.010 |
Biomarker
|
disease |
LHGDN |
Genetic variants of the IgA Fc receptor (FcalphaR, CD89) promoter in chronic hepatitis C patients.
|
17033823 |
2006 |
|
Hepatitis C, Chronic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants of the IgA Fc receptor (FcalphaR, CD89) promoter in chronic hepatitis C patients.
|
17033823 |
2006 |
|
Infection
|
0.010 |
Biomarker
|
group |
LHGDN |
Genetic variants of the IgA Fc receptor (FcalphaR, CD89) promoter in chronic hepatitis C patients.
|
17033823 |
2006 |
|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
|
IGA Glomerulonephritis
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
However, no association between CD89 gene polymorphisms and susceptibility to IgAN was detected.
|
20811333 |
2010 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
However, as IgA induces neutrophil recruitment, novel therapeutic strategies that aim to target the IgA Fc receptor FcαRI may fully unleash the potential of enlisting neutrophils as cytotoxic effector cells in antibody therapy of cancer.
|
29855035 |
2018 |