|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
On B-cells, ADAM10 cleavage of the low-affinity IgE receptor CD23 promotes allergy and asthma, cleavage of ICOS ligand impairs antibody responses, and cleavage of the BAFF-APRIL receptor transmembrane activator and CAML interactor, and BAFF receptor, reduce B-cell survival.
|
30013551 |
2018 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To determine whether CD23 plays a role in the inflammatory process in severe uncontrolled asthma and whether anti-IgE therapy modulates fc epsilon RII/CD23 expression in these patients.
|
29279058 |
2018 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Among the genes identified, variants in T-box 21 ( TBX21) and Fc fragment of IgE receptor II ( FCER2) contribute indirectly to the variability in the response to ICS by altering the inflammatory mechanisms in asthma, while other genes such as corticotropin releasing hormone receptor 1 ( CRHR1), nuclear receptor subfamily 3 group C member 1 ( NR3C1), stress induced phosphoprotein 1 ( STIP1), dual specificity phosphatase 1 (DUSP1), glucocorticoid induced 1 (GLCCI1), histone deacetylase 1 (HDAC), ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3), and vascular endothelial growth factors (VEGF) directly affect this variability through the anti-inflammatory mechanisms of ICS.
|
29251255 |
2017 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In contrast, the proportions of B cells with CD23 and CD21 expression were higher (P < .05) in patients with asthma compared with controls.
|
27026514 |
2016 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To cover the genetic information of FCER2, 21 single-nucleotide polymorphisms (SNPs) were genotyped by Illumina HumanHap300 BeadChip (5 SNPs) and the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS; 14 SNPs) in at least 1303 Caucasian children (651 asthmatics) (ISAAC II/ MAGICS population); genotypes of two SNPs were imputed.
|
24354852 |
2014 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic variations of the FCER2 gene and asthma susceptibility in north Indian children: a case-control study.
|
24102092 |
2013 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A SNP (rs2228137) (R62W) in FCER2 has been linked with severe exacerbations in asthmatics.
|
22059556 |
2011 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The association between the FCER2 T2206C variant and asthma-related hospitalizations in steroid-treated asthma appears robust and may also be associated with other indicators of lack of ICS efficacy such as asthma symptoms and a requirement for higher daily doses of ICS.
|
21958076 |
2011 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
An increase in CD25+ T-lymphocyte and CD23 B-lymphocyte populations after food allergen challenge may indicate their significant role in the pathogenesis of the active phase of the immunoinflammatory process in children with asthma and concomitant food allergy.
|
19571570 |
2009 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To determine whether variation in the low-affinity IgE receptor gene, FCER2, is associated with severe exacerbations defined as emergency department visits and/or hospitalizations in patients with asthma on ICSs.
|
17980418 |
2007 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
As assessed by shift in mean fluorescence, instillation of allergen in the asthmatic's airway further up-regulated Fc epsilon RII on alveolar macrophages by 151 +/- 7%.
|
1401914 |
1992 |