|
Mantle cell lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
SOX11-negative MCLs more often showed classic morphology (83% vs. 65%, P=0.005), were more often positive for CD23 (39% vs. 22%, P=0.02) and CD200 (60% vs. 9%, P=0.0001), and had a lower proliferation index (Ki67 23% vs. 33%, P=0.04).
|
30768440 |
2019 |
|
Mantle cell lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CD23+ MCL was also more often positive for CD200 (17% versus.
|
31054894 |
2019 |
|
Mantle cell lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CD200 was of better diagnostic performance (accuracy: 94.6%) in differentiating CLL from MCL compared with CD23 (accuracy: 93.3%).
|
28752619 |
2018 |
|
Mantle cell lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Reported findings of indolent presentation of MCL include: lack of B symptoms, normal serum lactic dehydrogenase (LDH) and β2-microglobulin levels (β2M), low MCL-International Prognostic Index (MIPI) score, maximum tumor diameter less than 3 cm, spleen size < 20 cm, positron emission tomography/computerized tomography with the Standard Uptake Value max <6, Ki-67 less than 30%, with some particular immunophenotype, such as CD5 and CD38 negative, markedly increased CD23 positive lymphocytes proportions, high expression of CD200, kappa light chain restriction, without C-myc, TP53 and NOTCH1/2 mutations, non-blastoid/pleomorphic histology, and no tumor growth on reevaluation every 2~3 months (followed for at least 6 months).
|
29246179 |
2017 |
|
Mantle cell lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
None of the 24 mantle cell lymphoma (MCL) cases, two being CD23-positive, expressed CD200 (median MFI: 10).
|
28422443 |
2017 |
|
Mantle cell lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using the disease-specific expression of CD5, CD23, and CD160, a score of 3 characterized CLL (diagnostic odds ratio, 1430); a score of 0 excluded CLL, MCL, and HCL; and the CD23/CD5 ratio differentiated CLL from leukemic CD23(+) MCL.
|
21715317 |
2011 |
|
Mantle cell lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
One blastoid variant MCL was CD23+, and one was FMC7-.
|
19846810 |
2009 |
|
Mantle cell lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In 14 CD23 negative cases IGH/BCL1 FISH detected t(11;14) and was confirmed to be mantle cell lymphoma.
|
16487171 |
2006 |
|
Mantle cell lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The classic MCL had typical morphologic features and immunophenotype (kappa sIg light chain-restricted and CD5+; CD10- and CD23-).
|
15272540 |
2004 |
|
Mantle cell lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
On the basis of different expression patterns, we identified four diagnostic clusters (C) characterized by distinct clinico-biological features and different prognoses: C1 (149 patients) identified most classical B cell chronic lymphocytic leukemias (CLL-type cluster; SIg(dim)/CD5+/CD23+); C2, 38 patients whose clinico-hematological characteristics were intermediate between C1 and C3 (CLL-variant cluster; SIg(bright)/CD5+/CD23+/-or SIg(dim)/CD5-/-/CD23 indifferent); C3 (16 patients) most situations consistent with mantle cell lymphoma in leukemic phase (MCL-type cluster; SIg(bright)/CD5+/CD23-); and C4, 55 cases, most of whom were consistent with leukemic phase lymphoplasmacytic/splenic marginal zone lymphomas (LP/S-type cluster; SIg(bright)/CD5-/+/CD23 indifferent).
|
12529669 |
2003 |
|
Mantle cell lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Guess what: Chronic 13q14.3+/CD5-/CD23+ lymphocytic leukemia in blood and t(11;14)(q13;q32)+/CD5+/CD23- mantle cell lymphoma in lymph nodes!
|
12500296 |
2003 |
|
Mantle cell lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In morphological variants of MCL the immunohistochemical constellation with CD5-positivity and CD23-negativity is a helpful and decisive diagnostic aid to differentiate MCL from other B-cell-lymphomas, e.g. lymphocytic lymphomas (B-CLL).
|
12688344 |
2003 |
|
Mantle cell lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Unexpectedly high values were found in few CLL/SLL cases and in many CD23+ lymphomas with MCL morphologic features.
|
11863220 |
2002 |
|
Mantle cell lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
By flow cytometry, the immunophenotype was compatible with MCL (i.e.CD5+CD20+CD23-FMC7+).
|
12127561 |
2002 |
|
Mantle cell lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
RQ-PCR allows rapid, simple and accurate quantification of CyD1 and CD23 expression, even from small samples, and is thus useful for the diagnosis of MCL and CLL.
|
12127555 |
2002 |
|
Mantle cell lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In both cases, immunohistochemistry (CD20+, CD5+, cyclin D1+, CD10-, and CD23-), and demonstration of clonal immunoglobulin heavy chain and bcl-1 gene rearrangements by PCR analysis confirmed the diagnosis of mantle cell lymphoma.
|
11504842 |
2001 |
|
Mantle cell lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Large cell variants of B-cell lymphoma/leukemia with a mantle cell immunophenotype (CD5+, CD23-), including but not limited to blastic MCL, prolymphocytoid MCL, blastic mantle cell leukemia, and prolymphocytic mantle cell leukemia, are not as well characterized.
|
11260626 |
2001 |
|
Mantle cell lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The cells show surface Ig (usually IgM), B-cell-associated antigens and display the CD5-, CD23- and CD10- phenotype, which allows for differential diagnosis from B-CLL and mantle cell lymphoma. t(9;14)(p13;q32) chromosomal translocation has been found in 50% of all LPL cases.
|
11718214 |
2001 |
|
Mantle cell lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Three CCND1-positive SLVL demonstrated immunophenotypic features similar to mantle cell lymphoma (MCL) but the majority differed in their CD5 negativity or CD23 positivity.
|
9674745 |
1998 |