FCGR1A, Fc fragment of IgG receptor Ia, 2209

N. diseases: 141; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.300 Biomarker disease CTD_human Systems level analysis and identification of pathways and networks associated with liver fibrosis. 25380136 2014
CUI: C0006663
Disease: Calcinosis
Calcinosis 		0.300 Biomarker phenotype CTD_human Raloxifene attenuates Gas6 and apoptosis in experimental aortic valve disease in renal failure. 21335463 2011
CUI: C0018824
Disease: Heart valve disease
Heart valve disease 		0.300 Biomarker group CTD_human Raloxifene attenuates Gas6 and apoptosis in experimental aortic valve disease in renal failure. 21335463 2011
CUI: C0263628
Disease: Tumoral calcinosis
Tumoral calcinosis 		0.300 Biomarker disease CTD_human Raloxifene attenuates Gas6 and apoptosis in experimental aortic valve disease in renal failure. 21335463 2011
CUI: C0521174
Disease: Microcalcification
Microcalcification 		0.300 Biomarker phenotype CTD_human Raloxifene attenuates Gas6 and apoptosis in experimental aortic valve disease in renal failure. 21335463 2011
CUI: C0087031
Disease: Juvenile-Onset Still Disease
Juvenile-Onset Still Disease 		0.300 Biomarker disease CTD_human Gene expression signatures in polyarticular juvenile idiopathic arthritis demonstrate disease heterogeneity and offer a molecular classification of disease subsets. 19565504 2009
CUI: C3495559
Disease: Juvenile arthritis
Juvenile arthritis 		0.300 Biomarker disease CTD_human Gene expression signatures in polyarticular juvenile idiopathic arthritis demonstrate disease heterogeneity and offer a molecular classification of disease subsets. 19565504 2009
CUI: C3714758
Disease: Juvenile psoriatic arthritis
Juvenile psoriatic arthritis 		0.300 Biomarker disease CTD_human Gene expression signatures in polyarticular juvenile idiopathic arthritis demonstrate disease heterogeneity and offer a molecular classification of disease subsets. 19565504 2009
CUI: C4552091
Disease: Polyarthritis, Juvenile, Rheumatoid Factor Negative
Polyarthritis, Juvenile, Rheumatoid Factor Negative 		0.300 Biomarker disease CTD_human Gene expression signatures in polyarticular juvenile idiopathic arthritis demonstrate disease heterogeneity and offer a molecular classification of disease subsets. 19565504 2009
CUI: C4704862
Disease: Polyarthritis, Juvenile, Rheumatoid Factor Positive
Polyarthritis, Juvenile, Rheumatoid Factor Positive 		0.300 Biomarker disease CTD_human Gene expression signatures in polyarticular juvenile idiopathic arthritis demonstrate disease heterogeneity and offer a molecular classification of disease subsets. 19565504 2009
CUI: C0242488
Disease: Acute Lung Injury
Acute Lung Injury 		0.200 Biomarker disease RGD Delay of LPS-induced acute lung injury resolution by soluble immune complexes is neutrophil dependent. 19106808 2009
CUI: C0003865
Disease: Arthritis, Adjuvant-Induced
Arthritis, Adjuvant-Induced 		0.200 Biomarker disease CTD_mouse FcgammaRI up-regulation induced by local adenoviral-mediated interferon-gamma production aggravates chondrocyte death during immune complex-mediated arthritis. 12875993 2003
CUI: C0971858
Disease: Arthritis, Collagen-Induced
Arthritis, Collagen-Induced 		0.200 Biomarker disease CTD_mouse FcgammaRI up-regulation induced by local adenoviral-mediated interferon-gamma production aggravates chondrocyte death during immune complex-mediated arthritis. 12875993 2003
CUI: C0993582
Disease: Arthritis, Experimental
Arthritis, Experimental 		0.200 Biomarker disease CTD_mouse FcgammaRI up-regulation induced by local adenoviral-mediated interferon-gamma production aggravates chondrocyte death during immune complex-mediated arthritis. 12875993 2003
CUI: C0036690
Disease: Septicemia
Septicemia 		0.100 Biomarker disease BEFREE Although no single, or even a combination of biomarkers has been validated for the diagnosis of sepsis, multiple studies have shown the high specificity of CD64 expression on neutrophils (nCD64) to sepsis. 31094395 2019
CUI: C0036690
Disease: Septicemia
Septicemia 		0.100 AlteredExpression disease BEFREE E coli internalization was not increased in monocytes from patients with SIRS/sepsis, despite increased numbers of circulating neutrophils and monocytes (P < 0.05) and overexpression of CD64 and CD69 in neutrophils (P < 0.05), TREM-1 (P < 0.01), CD69 (P < 0.001), and CCR7 (P < 0.05). 30601330 2019
CUI: C0036690
Disease: Septicemia
Septicemia 		0.100 AlteredExpression disease BEFREE The area under Receiver Operating Characteristic (ROC) curve (AUC) was 0.928 and 0.934 for neutrophil CD64 expression and CD64 + neutrophil population, respectively, indicating an excellent diagnosis ability for sepsis. 30262053 2019
CUI: C0036690
Disease: Septicemia
Septicemia 		0.100 Biomarker disease BEFREE Detection of culture-negative sepsis in clinical blood samples using a microfluidic assay for combined CD64 and CD69 cell capture. 30947986 2019
CUI: C0036690
Disease: Septicemia
Septicemia 		0.100 Biomarker disease BEFREE Only CD64 index was an independent predictor of sepsis, though with modest sensitivity and specificity (78% and 70%, respectively). 30871305 2019
CUI: C0036690
Disease: Septicemia
Septicemia 		0.100 AlteredExpression disease BEFREE In contrast, monocyte CD64 and CD14 expression was unaltered in sepsis and was not associated with mortality risk. 31584643 2019
CUI: C0036690
Disease: Septicemia
Septicemia 		0.100 Biomarker disease BEFREE Original studies reporting the performance of neutrophil CD64 for sepsis diagnosis in adult patients were retained. 30623257 2019
CUI: C0036690
Disease: Septicemia
Septicemia 		0.100 Biomarker disease BEFREE Association of the early absolute CD64-expressing neutrophil count and sepsis outcome. 31011855 2019
CUI: C0243026
Disease: Sepsis
Sepsis 		0.100 Biomarker disease BEFREE Association of the early absolute CD64-expressing neutrophil count and sepsis outcome. 31011855 2019
CUI: C0243026
Disease: Sepsis
Sepsis 		0.100 AlteredExpression disease BEFREE E coli internalization was not increased in monocytes from patients with SIRS/sepsis, despite increased numbers of circulating neutrophils and monocytes (P < 0.05) and overexpression of CD64 and CD69 in neutrophils (P < 0.05), TREM-1 (P < 0.01), CD69 (P < 0.001), and CCR7 (P < 0.05). 30601330 2019
CUI: C0243026
Disease: Sepsis
Sepsis 		0.100 Biomarker disease BEFREE Only CD64 index was an independent predictor of sepsis, though with modest sensitivity and specificity (78% and 70%, respectively). 30871305 2019