|
Schizophrenia
|
0.310 |
Biomarker
|
disease |
BEFREE |
Implementing this systematic approach, we: (i) discovered 177 putative SZ risk genes in brain, 28 of which map to linked chromosomal loci; (ii) delineated six biological processes and 12 molecular functions that may be particularly disrupted in the illness; (iii) identified 123 putative SZ biomarkers in blood, 6 of which (BTG1, GSK3A, HLA-DRB1, HNRPA3, SELENBP1, and SFRS1) had corresponding differential expression in brain; (iv) verified the differential expression of the strongest candidate SZ biomarker (SELENBP1) in blood; and (v) demonstrated neuronal and glial expression of SELENBP1 protein in brain.
|
16223876 |
2005 |
|
Schizophrenia
|
0.310 |
Biomarker
|
disease |
CTD_human |
Implementing this systematic approach, we: (i) discovered 177 putative SZ risk genes in brain, 28 of which map to linked chromosomal loci; (ii) delineated six biological processes and 12 molecular functions that may be particularly disrupted in the illness; (iii) identified 123 putative SZ biomarkers in blood, 6 of which (BTG1, GSK3A, HLA-DRB1, HNRPA3, SELENBP1, and SFRS1) had corresponding differential expression in brain; (iv) verified the differential expression of the strongest candidate SZ biomarker (SELENBP1) in blood; and (v) demonstrated neuronal and glial expression of SELENBP1 protein in brain.
|
16223876 |
2005 |
|
Silicosis
|
0.200 |
Biomarker
|
disease |
RGD |
[Differential analysis of two-dimensional gel electrophoresis profiles in lung tissue of rats exposed to silica early].
|
19534998 |
2009 |
|
Multiple Endocrine Neoplasia Type 2a
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The genetic loci RET, D10S94, and D10S102 from human chromosome 10q11.2 are very closely linked to a locus responsible for the multiple endocrine neoplasia type 2 (MEN2A and MEN2B) and medullary thyroid carcinoma (MTC1) familial cancer syndromes.
|
8093642 |
1993 |
|
Multiple Endocrine Neoplasia Type 2a
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
We have constructed a long-range contig of cosmid and YAC clones around D10S102, a locus that is tightly linked to the gene responsible for multiple endocrine neoplasia type 2A (MEN2A).
|
1346780 |
1992 |
|
Multiple Endocrine Neoplasia Type 2a
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
No recombination was observed between the MEN2A locus and either of the four loci D10Z1 (lod score 12.79), D10S102 (lod score 6.38), D10S94 (lod score 7.76), and D10S34 (lod score 5.94).
|
1353939 |
1992 |
|
Amyotrophic Lateral Sclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Another hnRNP protein, hnRNPA3, has been found to be associated with the ALS/frontotemporal dementia protein C9orf72.
|
29131108 |
2017 |
|
Motor Neuron Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Heterogeneous ribonuclear protein A3 (hnRNP A3) is present in dipeptide repeat protein containing inclusions in Frontotemporal Lobar Degeneration and Motor Neurone disease associated with expansions in C9orf72 gene.
|
28431575 |
2017 |
|
Frontotemporal Lobar Degeneration
|
0.010 |
Biomarker
|
disease |
BEFREE |
Heterogeneous ribonuclear protein A3 (hnRNP A3) is present in dipeptide repeat protein containing inclusions in Frontotemporal Lobar Degeneration and Motor Neurone disease associated with expansions in C9orf72 gene.
|
28431575 |
2017 |
|
Familial (FPAH)
|
0.010 |
Biomarker
|
disease |
BEFREE |
Genetic and Pathological Assessment of hnRNPA1, hnRNPA2/B1, and hnRNPA3 in Familial and Sporadic Amyotrophic Lateral Sclerosis.
|
29131108 |
2017 |
|
Amyotrophic Lateral Sclerosis, Sporadic
|
0.010 |
Biomarker
|
disease |
BEFREE |
Genetic and Pathological Assessment of hnRNPA1, hnRNPA2/B1, and hnRNPA3 in Familial and Sporadic Amyotrophic Lateral Sclerosis.
|
29131108 |
2017 |
|
GRN-related frontotemporal dementia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Heterogeneous ribonuclear protein A3 (hnRNP A3) is present in dipeptide repeat protein containing inclusions in Frontotemporal Lobar Degeneration and Motor Neurone disease associated with expansions in C9orf72 gene.
|
28431575 |
2017 |
|
Lung Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Expression of hnRNPA3 was the lowest, although its transcript levels were the most constant. hnRNPA/B transcript levels in lung tumor cell lines responded to changes in the microenvironment; however, hnRNPB1 transcript levels relative to hnRNPA2 expression did no change in all tested stress conditions, indicating that the alternative splicing between these isoforms was constant. hnRNPA1, A2, and B1 transcript levels were upregulated under serum deprivation conditions; possibly to promote a migration phenotype.
|
24246049 |
2014 |
|
Medullary carcinoma of thyroid
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The genetic loci RET, D10S94, and D10S102 from human chromosome 10q11.2 are very closely linked to a locus responsible for the multiple endocrine neoplasia type 2 (MEN2A and MEN2B) and medullary thyroid carcinoma (MTC1) familial cancer syndromes.
|
8093642 |
1993 |
|
Familial medullary thyroid carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The genetic loci RET, D10S94, and D10S102 from human chromosome 10q11.2 are very closely linked to a locus responsible for the multiple endocrine neoplasia type 2 (MEN2A and MEN2B) and medullary thyroid carcinoma (MTC1) familial cancer syndromes.
|
8093642 |
1993 |
|
Multiple endocrine neoplasia Type 2
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The genetic loci RET, D10S94, and D10S102 from human chromosome 10q11.2 are very closely linked to a locus responsible for the multiple endocrine neoplasia type 2 (MEN2A and MEN2B) and medullary thyroid carcinoma (MTC1) familial cancer syndromes.
|
8093642 |
1993 |