PHACTR1, phosphatase and actin regulator 1, 221692

N. diseases: 59; N. variants: 28
Disease: Arteriosclerosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.040 Biomarker disease BEFREE Carotid plaque is a hallmark of advanced carotid atherosclerosis and there is evidence of phosphatase and actin regulator 1 (PHACTR1) involvement in the processes that lead to atherosclerosis. 31200082 2019
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.040 Biomarker disease BEFREE Here, we sought to characterize PHACTR1 splicing pattern in atherosclerosis-relevant human cells. 29884117 2018
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.040 Biomarker disease BEFREE However, the underlying mechanism of PHACTR1 in atherosclerosis remains unknown. 30293016 2018
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.040 Biomarker disease BEFREE Our data demonstrate that PHACTR1 is a key atherosclerosis candidate gene since it is regulated by atherogenic stimuli in macrophages and endothelial cells and we identify an effect of the genetic risk variant on PHACTR1 expression in macrophages that is similar to that of an inflammatory stimulus. 27187934 2016