|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Phosphatase and actin regulator 1 rs9349379 polymorphism is associated with an elevated susceptibility to coronary artery disease: a meta-analysis.
|
31278837 |
2019 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
PHACTR1 intronic variants have been associated with coronary artery disease and carotid dissection.
|
31200082 |
2019 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
PHACTR1 gene polymorphism with the risk of coronary artery disease in Chinese Han population.
|
30777881 |
2019 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
PHACTR1 genotype predicts coronary artery disease in patients with familial hypercholesterolemia.
|
29784573 |
2019 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies have showed that genetic variants in phosphatase and actin regulator 1 (PHACTR1) are associated with coronary artery disease and myocardial infarction.
|
30293016 |
2018 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies (GWASs) implicate the PHACTR1 locus (6p24) in risk for five vascular diseases, including coronary artery disease, migraine headache, cervical artery dissection, fibromuscular dysplasia, and hypertension.
|
28753427 |
2017 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
PHACTR1 and SLC22A3 gene polymorphisms are associated with reduced coronary artery disease risk in the male Chinese Han population.
|
27893421 |
2017 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Recent genome-wide association studies (GWAS) in European populations have indicated that the rs12526453 polymorphism located in phosphatase and actin regulator 1 gene (PHACTR1), mapping to chromosome 6p24 and rs7865618 polymorphism in the cyclin-dependent kinase inhibitor B antisense RNA 1 gene (CDKN2B-AS1) on 9p21.3 are associated with coronary heart disease (CHD).
|
28287809 |
2017 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Coronary artery disease associated gene Phactr1 modulates severity of vascular calcification in vitro.
|
28720499 |
2017 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The top variant, rs9349379, is intronic to PHACTR1, a risk locus for coronary artery disease, migraine, and cervical artery dissection.
|
27792790 |
2016 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Recently, certain polymorphisms in the phosphatase and actin regulator 1 (PHACTR1) gene have been shown to be associated with CVD (i.e., coronary artery disease, coronary artery calcification, early onset myocardial infarction, cervical artery dissection and hypertension) in different ethnic groups.
|
27876132 |
2016 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
I have read with interest the recent paper by Han and coworkers on the putative effects of a PHACTR1 variant in the context of coronary artery disease.
|
25938970 |
2015 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The phosphatase and actin regulator 1 (PHACTR1) locus is a very commonly identified hit in genome-wide association studies investigating coronary artery disease and myocardial infarction (MI).
|
26098115 |
2015 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
|
24262325 |
2014 |
|
Coronary heart disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
Four SNPs in regions previously implicated in CAC/CHD (at 9p21 and PHACTR1) in EA reached nominal significance for CAC in AA, with concordant direction.
|
23870195 |
2013 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We demonstrate that SNPs near 9p21 and in PHACTR1 that have previously been shown to be associated with CHD are strongly associated with CAC in the Heinz Nixdorf Recall Study cohort.
|
23394302 |
2013 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.
|
22751097 |
2012 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.
|
22751097 |
2012 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study in a Lebanese cohort confirms PHACTR1 as a major determinant of coronary artery stenosis.
|
22745674 |
2012 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study in a Lebanese cohort confirms PHACTR1 as a major determinant of coronary artery stenosis.
|
22745674 |
2012 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.
|
21378988 |
2011 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study in europeans and South asians identifies 5 new Loci for coronary artery disease.
|
21846871 |
2011 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
|
21347282 |
2011 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Five single-nucleotide polymorphisms, rs4977574 (CDKN2A/2B), rs12526453 (PHACTR1), rs646776 (CELSR2-PSRC1-SORT1), rs2259816 (HNF1A), and rs11206510 (PCSK9) showed directionally consistent associations with CHD in the 3 studies, with combined odds ratios (ORs) ranging from 1.17 to 1.25 (p = 0.03 to 0.0002).
|
22152955 |
2011 |
|
Coronary heart disease
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
|
21378990 |
2011 |