FDPS, farnesyl diphosphate synthase, 2224

N. diseases: 83; N. variants: 3
Disease: Malignant Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.050 Biomarker group BEFREE Experimental results revealed that VS-4 could better target the FPPS high-expressing colon LoVo and HCT116 cancer cell lines with IC<sub>50</sub> of 51.772 ± 0.473 and 43.553 ± 1.027 μM, respectively, whereas the IC<sub>50</sub> value against FPPS low expressing MDA-MB-231 cells was >100 μM. 31785819 2020
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.050 Biomarker group BEFREE To date, the mechanistic, functional, and clinical significance of FDPS in cancer remains unexplored. 30914801 2019
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.050 AlteredExpression group BEFREE FDPS mRNA in patients with glioblastoma was associated with malignancy in three independent microarray data sets. 30333528 2018
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.050 Biomarker group BEFREE With the effort to develop a more refined map of the connectivity between signal transduction pathways and metabolic networks in cancer FDPS as a new candidate metabolic oncogene in glioblastoma, might suggest to further target MVA pathway as valid therapeutic tool. 29075041 2017
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.050 GeneticVariation group BEFREE Sixteen genes have been associated with cancer, with five specifically associated with prostate cancer (BTG2, IGFBP3, SIRT1, MXI1, and FDPS). 24713434 2014