FDPS, farnesyl diphosphate synthase, 2224

N. diseases: 83; N. variants: 3
Disease: Adult Glioblastoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.030 AlteredExpression disease BEFREE FDPS mRNA in patients with glioblastoma was associated with malignancy in three independent microarray data sets. 30333528 2018
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.030 Biomarker disease BEFREE With the effort to develop a more refined map of the connectivity between signal transduction pathways and metabolic networks in cancer FDPS as a new candidate metabolic oncogene in glioblastoma, might suggest to further target MVA pathway as valid therapeutic tool. 29075041 2017
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.030 Biomarker disease BEFREE The present results suggest that FPPS plays an important role in apoptotic cell death of cancer cells by blocking the JNK signaling cascade and activating mevalonate metabolism in paclitaxel-treated glioblastoma cells. 20298756 2010