|
ovarian neoplasm
|
0.350 |
Biomarker
|
disease |
BEFREE |
These observations suggest a crucial role for cancer-associated fibroblasts and fibroblast growth factor-1/fibroblast growth factor receptor 4 signaling in the progression of ovarian cancer.
|
28718374 |
2017 |
|
ovarian neoplasm
|
0.350 |
Biomarker
|
disease |
CTD_human |
Other groups have identified FGF1 as a relevant risk factor in ovarian cancer.
|
25174399 |
2015 |
|
ovarian neoplasm
|
0.350 |
Biomarker
|
disease |
BEFREE |
WNT7A/β-catenin signaling induces FGF1 and influences sensitivity to niclosamide in ovarian cancer.
|
25174399 |
2015 |
|
ovarian neoplasm
|
0.350 |
GeneticVariation
|
disease |
BEFREE |
In particular, FGF1 [fibroblast growth factor 1 (acidic)] SNP rs7727832 showed the most significant association with ovarian cancer (odds ratio, 2.27; 95% CI, 1.31-3.95).
|
24146310 |
2014 |
|
ovarian neoplasm
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
We used qRT-PCR analysis to assess intertumour differences in the expression of fibroblast growth factor 1 (FGF1) and additional candidate genes in human ovarian tumours (n=187), and correlated individuality in gene expression with tumour histology, chemotherapy response and survival.
|
22990650 |
2012 |
|
ovarian neoplasm
|
0.350 |
Biomarker
|
disease |
LHGDN |
Amplification of FGF-1 at 5q31 in ovarian cancer tissues leads to increased angiogenesis, and autocrine stimulation of cancer cells, which may result in poorer overall survival in patents with high-grade advanced stage serous ovarian cancer.
|
17538174 |
2007 |
|
Malignant neoplasm of ovary
|
0.330 |
Biomarker
|
disease |
BEFREE |
These observations suggest a crucial role for cancer-associated fibroblasts and fibroblast growth factor-1/fibroblast growth factor receptor 4 signaling in the progression of ovarian cancer.
|
28718374 |
2017 |
|
Malignant neoplasm of ovary
|
0.330 |
Biomarker
|
disease |
CTD_human |
High expression of WNT7A and FGF1 are correlated in ovarian carcinomas and poor overall patient survival.
|
25174399 |
2015 |
|
Malignant neoplasm of ovary
|
0.330 |
Biomarker
|
disease |
BEFREE |
WNT7A/β-catenin signaling induces FGF1 and influences sensitivity to niclosamide in ovarian cancer.
|
25174399 |
2015 |
|
Malignant neoplasm of ovary
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
In particular, FGF1 [fibroblast growth factor 1 (acidic)] SNP rs7727832 showed the most significant association with ovarian cancer (odds ratio, 2.27; 95% CI, 1.31-3.95).
|
24146310 |
2014 |
|
Pulmonary Fibrosis
|
0.320 |
Biomarker
|
disease |
BEFREE |
In this study, we explore the mechanisms underlying the anti-fibrogenic effect of FGF-1 in pulmonary fibrosis in vitro and in vivo by prolonged transient overexpression of FGF-1 (AdFGF-1) and TGF-β1 (AdTGF-β1) using adenoviral vectors.
|
27425145 |
2016 |
|
Pulmonary Fibrosis
|
0.320 |
Biomarker
|
disease |
CTD_human |
Gene expression of cytokines and growth factors in the lungs after paraquat administration in mice.
|
16324872 |
2006 |
|
Pulmonary Fibrosis
|
0.320 |
Biomarker
|
disease |
BEFREE |
These data suggest that aFGF may activate lung fibroblasts in a way of autocrine and, therefore, may be involved in the development of lung fibrosis.
|
7511497 |
1993 |
|
leukemia
|
0.310 |
Biomarker
|
disease |
CTD_human |
Zebrafish fgf1 is syntenic to human FGF1, which maps to a critically deleted region in human del(5q) syndrome posing an increased risk of leukemia to patients.
|
17219402 |
2007 |
|
Mesothelioma
|
0.310 |
Biomarker
|
disease |
CTD_human |
Treatment of MM cells with egr-1 short interfering RNA suppressed proliferation, which was overridden by exogenously added recombinant FGF-1 and, in particular, FGF-2.
|
15878867 |
2005 |
|
Myocardial Ischemia
|
0.310 |
Biomarker
|
disease |
CTD_human |
Cardioplegia prevents ischemia-induced transcriptional alterations of cytoprotective genes in rat hearts: a DNA microarray study.
|
16214533 |
2005 |
|
Mesothelioma
|
0.310 |
Biomarker
|
disease |
BEFREE |
FGF1 and FGF2 enhanced MM cell proliferation that was suppressed by alpha-TOS.
|
15144885 |
2004 |
|
Myocardial Ischemia
|
0.310 |
Biomarker
|
disease |
BEFREE |
The effect of native and non-mitogenic fibroblast growth factor-1 mutein (FGF-1 and m-FGF-1) on apoptosis assessed by terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) method was tested in a rat model of 20 min regional myocardial ischemia and 24h reperfusion.
|
9385115 |
1997 |
|
leukemia
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
Cloning and sequence analysis of the human acidic fibroblast growth factor gene and its preservation in leukemia patients.
|
1717925 |
1991 |
|
Weight Gain
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Different transcriptional control of metabolism and extracellular matrix in visceral and subcutaneous fat of obese and rimonabant treated mice.
|
19030233 |
2008 |
|
Alveolitis, Fibrosing
|
0.300 |
Biomarker
|
disease |
CTD_human |
Gene expression of cytokines and growth factors in the lungs after paraquat administration in mice.
|
16324872 |
2006 |
|
Hypotension
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Kinins are implicated of the hypotensive effect of acidic fibroblast growth factor.
|
9233905 |
1997 |
|
Brain Ischemia
|
0.200 |
Biomarker
|
disease |
RGD |
Protective effects of mutant of acidic fibroblast growth factor against cerebral ischaemia-reperfusion injury in rats.
|
19497570 |
2009 |
|
Reperfusion Injury
|
0.200 |
Biomarker
|
disease |
RGD |
Protective effects of mutant of acidic fibroblast growth factor against cerebral ischaemia-reperfusion injury in rats.
|
19497570 |
2009 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |