FGF1, fibroblast growth factor 1, 2246

N. diseases: 184; N. variants: 10
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.060 GeneticVariation disease BEFREE EM performance and hippocampal volume (HV) were characterized in patients with mild AD based on <i>APOE</i>-ε4 carrier status (<i>APOE</i>-ε4 carriers versus non-carriers) and <i>FGF1</i> single nucleotide polymorphism (<i>FGF1-</i>rs34011-GG versus <i>FGF1-</i>rs34011-A-allele carriers). 31164996 2019
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.060 GeneticVariation disease BEFREE A variant within FGF1 is associated with Alzheimer's disease in the Han Chinese population. 24464990 2014
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.060 Biomarker disease BEFREE Our data suggest that inhibition of expression or release of aFGF could have therapeutic potential by inhibiting inflammation in neurodegenerative diseases such as Alzheimer disease where many neuroinflammatory molecules are prominently expressed. 21990352 2011
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.060 GeneticVariation disease BEFREE Our data suggested no association between the FGF1 -1385 C>T polymorphism and AD risk in Chinese Han population. 20298684 2010
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.060 GeneticVariation disease BEFREE The results showed that the FGF1 gene is associated with autopsy-confirmed AD. 15358178 2004
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.060 GeneticVariation disease LHGDN The results showed that the FGF1 gene is associated with autopsy-confirmed AD. 15358178 2004
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.060 Biomarker disease BEFREE Immunohistochemical examination of postmortem brain tissue of Alzheimer's disease revealed that acidic fibroblast growth factor (aFGF) was specifically expressed in a subpopulation of reactive astrocytes which were congregated at the margin of the senile plaque. 7539161 1994