|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fibroblast growth factor 2 (FGF2) is one of the critical regulators of melanoma angiogenesis and metastasis; thus, it might be an effective anti-cancer strategy to explore FGF2-targeting drug candidates from existing drugs.
|
31035725 |
2019 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Basic fibroblast growth factor(bFGF) is an angiogenic factor, and up-regulated expression of bFGF plays a crucial role in the development and metastasis of melanoma.
|
29405828 |
2018 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fibroblast growth factor 2 (FGF2) has been shown to induce cell proliferation and angiogenesis of melanoma and other malignancies.
|
29184418 |
2017 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We also demonstrated that circulating levels of FGF2 were associated with non-melanoma tumor formation in vivo.
|
28783178 |
2017 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
FGF2 is involved in melanoma development and progression.
|
27558498 |
2017 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The rate of positive bFGF staining in patients with melanoma with lymph node metastasis was significantly higher compared with patients without lymph node metastasis.
|
28789380 |
2017 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data suggested that Epac1 in melanoma cells regulates melanoma progression via the HS-FGF2-mediated cell-cell communication.
|
24725364 |
2014 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The fibroblast growth factor-2 (FGF2)/FGF receptor (FGFR) system plays a pivotal role in melanoma, leading to autocrine/paracrine induction of tumor cell proliferation and angiogenesis.
|
24130051 |
2013 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Basic fibroblast growth factor and angiogenin are the potentially important angiogenic factors for melanoma progression and metastasis.
|
21528671 |
2011 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The majority of melanoma cell lines displayed overexpression of FGF2 but also FGF5 and FGF18 together with different isoforms of FGF receptors (FGFRs) 1-4.
|
21753785 |
2011 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We were furthermore able to demonstrate that bFGF-mediated induction of migration is achieved via activation of BMP4, thus determining BMP4 as major modulator of migration in melanoma.
|
20480203 |
2010 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Syndecan-2 expression was enhanced by fibroblast growth factor-2, which is known to stimulate melanoma cell migration; however, alpha-melanocyte-stimulating hormone decreased syndecan-2 expression and melanoma cell migration and invasion in a melanin synthesis-independent manner.
|
19641225 |
2009 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These data indicate that stimulation of VEGF protein secretion in response to bFGF overexpression may contribute to increased vascularization and enhanced aggressiveness in melanoma.
|
19478386 |
2009 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that essential in melanoma progression FGF-2, specifically regulates melanoma cell ability to migrate through a syndecan-4-dependent mechanism.
|
19110070 |
2009 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
FGF1, FGF2, and their FGFR1 receptor were strongly expressed in the primary uveal melanomas.
|
19029025 |
2009 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Additionally, alterations of SOCS-1 expression profoundly affected the expression of matrix metalloproteinase-2 (MMP-2), basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (VEGF) and the melanoma cell invasion and angiogenesis.
|
19047140 |
2008 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Two human melanoma cell lines, M14 and 1F6, known to have low endogenous basic fibroblast growth factor expression and slow growth as subcutaneous xenografts, were stably transfected with vectors encoding either the 18 kDa or all (ALL) isoform proteins of human basic fibroblast growth factor.
|
17505261 |
2007 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Two human melanoma cell lines, M14 and 1F6, known to have low endogenous basic fibroblast growth factor expression and slow growth as subcutaneous xenografts, were stably transfected with vectors encoding either the 18 kDa or all (ALL) isoform proteins of human basic fibroblast growth factor.
|
17505261 |
2007 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Basic fibroblast growth factor (bFGF) is a multifunctional protein and one of the most important growth factors in cutaneous melanoma development and progression.
|
17938272 |
2007 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Interestingly, in a panel of human melanoma cell lines, a significant correlation (r(2)=0.883, P<0.05) between bFGF and CD13 mRNA and protein expression was detected.
|
16685268 |
2006 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
Finally, cell exposure to HPSE or to HPSE-degraded HS modulated FGF2-induced angiogenesis in melanoma.
|
16867222 |
2006 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Quantitative PCR analysis of 6 related human melanoma clones with various levels of alphaIIbbeta3 integrin expressions revealed a correlation between the alphaIIb protein and bFGF mRNA expressions.
|
15761867 |
2005 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
Taken together, our results indicate an essential role for soluble factors, mainly IL-1alpha and bFGF, in the stimulation of dermal fibroblasts by human melanoma cells to secrete MMP-1.
|
15737206 |
2005 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We tested three melanoma cell lines (A375, IIB and UCD) that express FGF2 and respond to exogenous FGF2 with increased proliferation.
|
15091189 |
2004 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We also demonstrate that: (1) among the major pro-angiogenic genes, FGF-2 was not increased before or after irradiation and vascular endothelial growth factor strongly inhibited after irradiation; (2) expression of two important metalloproteinases, matrix metalloproteinase 2 and 9, involved in melanoma metastasis were decreased before and after irradiation; (3) expression of their major inhibitor, tissue inhibitor of metalloproteinase, was mainly upregulated; and (4) that invasion of BRCA1 downregulated cells was modified.
|
15009718 |
2004 |