Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The role of substrate sulfation and FGF-2 loading on the growth of A172 (human glioblastoma multiforme), SH-SY5Y (human neuroblastoma), and PC-12 (rat pheochromocytoma) cell lines was evaluated in vitro using proliferation and neurite outgrowth assessment.
|
31407727 |
2019 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Taken together, our data suggest that up-regulation of MALAT1 expression in human neuroblastoma cells under hypoxic conditions increases FGF2 expression and promotes vasculature formation, and therefore plays an important role in tumor-driven angiogenesis.
|
26848616 |
2016 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These studies characterize a coreceptor function for TβRIII in FGF2-mediated neuronal differentiation, while identifying potential therapeutic targets and clinical biomarkers for neuroblastoma.
|
24216509 |
2013 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, FGF-2 has been described to induce "neuronal-like" differentiation and trigger apoptosis in neuroblastoma SK-N-MC cells.
|
21506108 |
2011 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, we have shown for the first time that FGF-2 induces differentiation of neuroblastoma cells via activation of a complex gene expression program enabling modulation of cell cycle, transcription factors, and suppression of the cancer phenotype.
|
19477940 |
2009 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we demonstrated that treatment of the human neuroblastoma cell line, SK-N-MC, with fibroblast growth factor-2 (FGF-2) results in induction of BAG3 expression.
|
18469860 |
2008 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interaction between ERK and GSK3beta mediates basic fibroblast growth factor-induced apoptosis in SK-N-MC neuroblastoma cells.
|
18263590 |
2008 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The treatment of NB cells with FGF2 variably affects biological characteristics such as growth and differentiation, while in PNET/ES, FGF2 predominantly induces apoptosis.
|
14694527 |
2004 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that VEGF-A, but not VEGF-C, bFGF, or PD-ECGF/TP, may be associated with progression of NB.
|
11768614 |
2001 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The actions of basic fibroblast growth factor (bFGF) and ciliary neurotrophic factor (CNTF) on tyrosine hydroxylase (TH) gene expression were studied using IMR-32 neuroblastoma cells.
|
7760021 |
1995 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Basic fibroblast growth factor enhances nerve growth factor receptor gene promoter activity in human neuroblastoma cell line CHP100.
|
1314950 |
1992 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results demonstrate that enhanced MYCN expression confers to neuroblastoma cells the ability to respond to bFGF, possibly by inducing functional FGF receptors.
|
1656953 |
1991 |