|
Mammary Neoplasms
|
0.390 |
Biomarker
|
group |
CTD_human |
Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase.
|
21936542 |
2011 |
|
Mammary Neoplasms
|
0.390 |
AlteredExpression
|
group |
BEFREE |
INT2 and ERBB2 amplification and ERBB2 expression in breast tumors from patients with different outcomes.
|
8750529 |
1996 |
|
Mammary Neoplasms
|
0.390 |
Biomarker
|
group |
BEFREE |
These three genes, c-myc, int-2/FGF3 (a marker for the 11q13 amplicon), and c-erbB-2/neu, were amplified in 37%, 14%, and 10% of breast tumors studied, respectively.
|
7892157 |
1994 |
|
Mammary Neoplasms
|
0.390 |
Biomarker
|
group |
BEFREE |
Amplifications of the int-2 oncogene were found in 2 SSR-positive and 1 SSR-negative breast tumor.
|
8099570 |
1993 |
|
Mammary Neoplasms
|
0.390 |
Biomarker
|
group |
BEFREE |
This is the first report of an association between amplification of the int-2 oncogene in breast tumours and a significantly increased risk of death from breast cancer, and suggests that int-2 may be useful for identifying breast-cancer patients having a poor prognosis.
|
8449602 |
1993 |
|
Mammary Neoplasms
|
0.390 |
Biomarker
|
group |
BEFREE |
Prevalence of amplification of the oncogenes c-myc, HER2/neu, and int-2 in one thousand human breast tumours: correlation with steroid receptors.
|
1350457 |
1992 |
|
Mammary Neoplasms
|
0.390 |
AlteredExpression
|
group |
BEFREE |
A systematic study of primary human breast tumor DNA demonstrated that three proto-oncogenes or regions of the genome (c-myc, int-2, and c-erbB2) are frequently amplified and that there is loss of heterozygosity (LOH) on chromosomes 1p(37%), 1q(20%), 3p(30%), 7(41%), 11p(20%), 13q(30%), 17p(49%), 17q(29%), and 18q(34%).
|
1540899 |
1992 |
|
Mammary Neoplasms
|
0.390 |
Biomarker
|
group |
BEFREE |
Her-2/neu and INT2 proto-oncogene amplification in malignant breast tumors in relation to reproductive factors and exposure to exogenous hormones.
|
1920494 |
1991 |
|
Mammary Neoplasms
|
0.390 |
Biomarker
|
group |
BEFREE |
A single breast tumor showed amplification of int-2 oncogene only.
|
2915903 |
1989 |
|
Mammary Neoplasms
|
0.390 |
Biomarker
|
group |
BEFREE |
Amplification of c-myc, c-erbB-2, hst and int-2 proto-oncogenes was investigated in two independently collected breast tumor series comprising 292 carcinomas.
|
2554239 |
1989 |