FGF4, fibroblast growth factor 4, 2249

N. diseases: 86; N. variants: 0
Disease: Seminoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036631
Disease: Seminoma
Seminoma 		0.020 Biomarker disease BEFREE TGF-β1, EGF and FGF4 synergistically induce differentiation of the seminoma cell line TCam-2 into a cell type resembling mixed non-seminoma. 21649665 2011
CUI: C0036631
Disease: Seminoma
Seminoma 		0.020 AlteredExpression disease BEFREE There were significant differences in oncogene expression between seminomas and nonseminomas with c-kit being expressed in 24 of 30 (80%) seminomas but in only 3 of 40 (7%) nonseminomatous tumors (P = 0.0001, chi 2 test) and hst-1 being expressed in 24 of 38 (63%) nonseminomas but only 1 of 24 (4%) of seminomas (P = 0.0001, chi 2 test), demonstrating an inverse relationship in the expression pattern of these 2 oncogenes in human testicular germ cell tumors. 1706218 1991