FGF10, fibroblast growth factor 10, 2255

N. diseases: 152; N. variants: 28
Disease: Agenesis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0000846
Disease: Agenesis
Agenesis 		0.030 GeneticVariation disease BEFREE New pathogenic variant in the FGF10 gene in the agenesis of lacrimal and salivary gland syndrome: Ophthalmological and genetic study. 29053399 2018
CUI: C0000846
Disease: Agenesis
Agenesis 		0.030 GeneticVariation disease BEFREE There were associations between AXIN2, FGF3, FGF10, and FGFR2 with tooth agenesis [i.e., individuals who carried the polymorphic allele of FGFR2 (rs1219648) presented higher risk for having premolar agenesis (p = 0.02; OR = 1.8; 95% C.I., 1.1-3.0)]. 23169889 2013
CUI: C0000846
Disease: Agenesis
Agenesis 		0.030 GeneticVariation disease BEFREE Affected patients may have aplasia or hypoplasia or minimal involvement of these glands, as there is considerable variation in expressivity [M. Entesarian, et al., Mutations in the gene encoding fibroblast growth factor 10 are associated with aplasia of lacrimal and salivary glands, Nat.Genet.37 (2) (2005) 125-127]. 19376597 2009