|
Malignant Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Thus, TGF-β and FGF-2 may cooperate with each other and may regulate EMT of various kinds of cells in cancer microenvironment during cancer progression.
|
21224849 |
2011 |
|
Malignant Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Malignant tumors with deregulated FGF-2 expression such as prostate cancer are also frequently aneuploid.
|
23243019 |
2013 |
|
Malignant Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Expression of the fibroblast growth factor (FGF)-1, FGF-2, fibroblast growth factor receptor (FGFR)-1, and FGFR-2 genes has been reported in various cancers and is associated with poor outcomes in patients with solid tumors.
|
19082464 |
2009 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
Thus, TGF-β and FGF-2 may cooperate with each other and may regulate EMT of various kinds of cells in cancer microenvironment during cancer progression.
|
21224849 |
2011 |
|
Primary malignant neoplasm
|
0.060 |
GeneticVariation
|
group |
BEFREE |
We describe the construction of a CRAd with cancer specific gene transcriptional control using the CXCR4 gene promoter (TSP) and cancer specific mRNA translational control using a 5'-untranslated region (5'-UTR) element from the FGF-2 (Fibroblast Growth Factor-2) mRNA.
|
17508279 |
2008 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
To clarify the function of FGF-2 in the malignancy of tumor cells, we designed experiments to express antisense RNA in a hepatoma cell line.
|
7585554 |
1995 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
These observations combined, suggest a model according to which FGF-2 induces EMT, cell proliferation and cancer stem cell self-renewal by coupling the Akt3 and KDM2B-controlled pathways outlined above, in bladder carcinomas.
|
28515962 |
2017 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
Our results point to FGF13 as a novel target and useful prognostic guide for cancer therapy.
|
24113164 |
2013 |
|
Primary malignant neoplasm
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts (CAFs) promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1, which act on both stromal and tumor cells to enhance cancer cell survival, proliferation and migration.
|
21532615 |
2011 |
|
Adenoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
While normal pituitary expresses GFG but not FGF-2, pituitary adenomas express FGF-2 and have reduced levels of GFG; aggressive and recurrent adenomas expressed more FGF than GFG mRNA.
|
11266510 |
2001 |
|
Adenoma
|
0.020 |
Biomarker
|
group |
BEFREE |
Immunohistochemistry of the excised tumor revealed strong immunoreactivity for VEGF and FGF-2, two potent angiogenic factors, and CD31 (an endothelial marker) indicating high vascularization of the adenoma.
|
19172414 |
2009 |
|
Esophageal Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Overexpression of FGF-2 is associated with tumor recurrence and reduced survival after surgical resection of esophageal cancer, and these risks are reduced in tumors co-expressing the FGF antisense (FGF-AS) RNA.
|
17569023 |
2007 |
|
Esophageal Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
NCAM- and FGF-2-mediated FGFR1 signaling in the tumor microenvironment of esophageal cancer regulates the survival and migration of tumor-associated macrophages and cancer cells.
|
27317650 |
2016 |
|
Mammary Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Carcinoma-associated fibroblasts activate progesterone receptors and induce hormone independent mammary tumor growth: A role for the FGF-2/FGFR-2 axis.
|
18767044 |
2008 |
|
Mammary Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
The data presented propose that of the FGFs studied (FGF-1, -2, -4, -5, and -7), FGF-2 is the most attractive target for therapeutical strategies aimed at diminishing the contribution of stromal fibroblasts in the PA-directed breast tumor proteolysis.
|
12008951 |
2002 |
|
Chronic Kidney Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
Thus, inflammatory processes (TNF, IL-10), calcification inhibitors (CA2), the Wnt-pathway (FGF-2) and foremost, ECM components (HMGA1, VNN1, VCAN), impact pathobiological responses in arteries from children with CKD.
|
31311999 |
2019 |
|
Chronic Kidney Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
Association of FGF-2 Concentrations with Atheroma Progression in Chronic Kidney Disease Patients.
|
29519952 |
2018 |
|
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Although we found a trend towards reduced disease-free survival in patients with FGF-2 overexpressing esophageal adenocarcinomas, significantly worse disease-free survival was noted among patients whose tumors did not also overexpress the FGF-AS b isoform (p = 0.03).
|
17569023 |
2007 |
|
Brain Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
In this study we examined by QRT-PCR the mRNA expression of TGF-beta 1, IGF-1, EGF, FGF-2 and YY1 in human brain tumors.
|
19235591 |
2009 |
|
Carcinoma
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The same analyses also revealed that FGF-2 correlates negatively with the expression, mutation and copy number variations of FGFR-3, all of which are associated with non-invasive bladder carcinomas.
|
28515962 |
2017 |
|
Diabetes Mellitus
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The expression of FGF-2 in placenta and its presence in maternal blood are elevated in pregnancies complicated by diabetes and are greatest in diabetic pregnancies associated with retinopathy.
|
9704229 |
1998 |
|
Kidney Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Furthermore, the upregulation of FGF-BP by regenerating renal tubular epithelial cells may provide a mechanism by which the regenerative and angiogenic activity of FGF-2 in renal capillaries can be modulated in children with HIV-HUS and other renal disease.
|
16352855 |
2006 |
|
Liver neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
These results clearly argue for a key role of endogenous FGF-2 in transformation and tumorigenesis of the hepatoma cell line used in this study.
|
7585554 |
1995 |
|
Prostatic Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Immunofluorescence data and western blot analyses determined that a lentivirus containing a 5'UTR derived from FGF-2 is the best candidate for directing selective gene expression in the prostate tumors of PTEN(-/-) mice in vivo.
|
21921943 |
2012 |
|
Retinal Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The expression of FGF-2 in placenta and its presence in maternal blood are elevated in pregnancies complicated by diabetes and are greatest in diabetic pregnancies associated with retinopathy.
|
9704229 |
1998 |