Squamous cell carcinoma of lung
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
FGFR1 CNG (10.7%), FGFR1 mutation (2.7%), FGFR2 mutation (2.7%), FGFR4 mutation (5.3%), and FGFR3 fusion (1.3%) were detected in LSCC specimens by NGS.
|
27581340 |
2016 |
Squamous cell carcinoma of lung
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to elucidate if these tumors harbor amplifications of the fibroblast growth factor receptor 1 (FGFR1) gene, which has recently been identified as a potential therapeutic target in squamous cell lung cancer.
|
23913758 |
2014 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Frequency of FGFR1 amplification is similar in SqCC with and without lymph node metastases, but status in metastatic sites may be discordant from the primary in a small subset of cases, which may affect the decision to perform testing of metastatic SqCCs.
|
26712871 |
2016 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, we detected subclonal <i>NRAS</i> amplifications in 3 of 20 (15%) primary human <i>FGFR1</i>-amplified SQLC specimens.
|
28630215 |
2017 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our work therefore provides a rationale for the inhibition of MCL-1, BCL-XL, and FGFR1 to maximize therapeutic response in FGFR1-expressing lung SqCC.
|
29743589 |
2018 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
These studies show that FGFR1 amplification is common in squamous cell lung cancer, and that FGFR1 may represent a promising therapeutic target in non-small cell lung cancer.
|
21666749 |
2011 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
This review focuses on the emerging role of FGFR1 as a therapeutic target in lung squamous cell carcinoma and reviews current agents that are in clinical development for the treatment of FGFR-dependent cancer.
|
23469973 |
2013 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
FGFR1 amplification is a common genetic event occurring at a frequency of 16% in L-SCCs.
|
22499828 |
2012 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
A report in this issue of Science Translational Medicine reveals that amplification of the FGFR1 gene-which encodes fibroblast growth factor receptor 1-is a major oncogenic aberration in squamous cell lung cancer.
|
21160076 |
2010 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
The aim of the present study was to evaluate FGFR1, PIK3CA and SOX2 protein expression in SQCC and determine whether the expression of these can be used as prognostic biomarkers.
|
25384882 |
2015 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
FGFR1 amplification is not prognostic in resected lung squamous cell carcinoma patients.
|
24077455 |
2013 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Definition of a fluorescence in-situ hybridization score identifies high- and low-level FGFR1 amplification types in squamous cell lung cancer.
|
22684217 |
2012 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
This meta-analysis strongly suggests that FGFR1 amplification occurs more frequently in male, SQCC and smokers, and it is a risk factor for poor prognosis among Asian patients with SQCC.
|
26788508 |
2015 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Fibroblast growth factor receptor 1 (FGFR1) has been demonstrated to be a high-frequency targetable oncogene specific for smoking-associated lung cancers, present in over 20% of lung squamous cell carcinoma cases.
|
28483948 |
2017 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Eligible studies regarding incidence of FGFR1 amplification in lung SQCC and correlation between FGFR1 amplification and clinicopathological features or survival were extracted and analyzed.
|
25433983 |
2015 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Amplification of fibroblast growth factor receptor 1 (FGFR1) is one of the most frequent targets in lung squamous cell carcinoma (SQCC).
|
28558758 |
2017 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Fibroblast Growth Factor Receptor 1 (FGFR1) amplification frequently occurs in squamous cell carcinoma of the lung and represents a novel druggable therapeutic target in this and other malignancies.
|
23434054 |
2013 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
More recently oncogenic drivers, such as DDR2, FGFR1 and PI3KCA, have been characterized in squamous cell lung carcinoma (SCC) and target agents are currently under evaluation.
|
23930754 |
2013 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
FGFR1 amplification is more prevalent in late stage SQC patients but does not predict chemotherapy response.
|
28008744 |
2017 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this issue of Cancer Discovery, Malchers and colleagues perform a detailed characterization of 8p12 in squamous cell lung cancer and find remarkable genomic heterogeneity in this region, raising the possibility that other genes in addition to FGFR1 may play a role in squamous cell lung cancer.
|
24501305 |
2014 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, focal FGFR1 amplification is common in squamous cell lung cancer and associated with tumor growth and survival, suggesting that FGFR inhibitors may be a viable therapeutic option in this cohort of patients.
|
21160078 |
2010 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recently, the fibroblast growth factor receptor 1 (FGFR1) has been identified as the first actionable target in squamous cell lung cancer.
|
24584974 |
2014 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
FGFR1 amplification was found in 16% of a clinical cohort of squamous cell lung cancer patients.
|
23154548 |
2012 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, the FGFR1 amplification patterns in SCLC differs strongly from the previously described FGFR1 amplification pattern in squamous cell carcinoma of the lung, as positive SCLC harbor mostly homogeneous high-level amplifications.
|
23887299 |
2014 |
Squamous cell carcinoma of lung
|
0.400 |
Biomarker
|
disease |
BEFREE |
FGFR1 has been implicated in numerous cancer types including squamous cell lung cancer, a subset of non-small cell lung cancer with a dismal 5-year survival rate.
|
30257990 |
2019 |