FGFR3, fibroblast growth factor receptor 3, 2261

N. diseases: 654; N. variants: 55
Disease: Degenerative polyarthritis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.140 Biomarker disease BEFREE We also found that the FGFR1/FGFR3 ratio, which might contribute to the progression of osteoarthritis, was upregulated by IL-1β and downregulated by FGF18. 30273654 2019
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.140 Biomarker disease BEFREE Activated FGFR3 prevents subchondral bone sclerosis during the development of osteoarthritis in transgenic mice with achondroplasia. 28520086 2018
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.140 AlteredExpression disease BEFREE We further found that activated phospho-FGFR3 and -RSK2 were more highly observed in RA than in OA synovium. 29540697 2018
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.140 AlteredExpression disease BEFREE mTORC1 activation downregulates FGFR3 and PTH/PTHrP receptor in articular chondrocytes to initiate osteoarthritis. 28043938 2017
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.140 Biomarker disease HPO