|
Malignant tumor of cervix
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
There was more FHIT promoter methylation in cervical cancer than in cervical intraepithelial neoplasia lesions and normal controls (odds ratio = 8.0, p = 0.055; odds ratio = 10.75, p < 0.001, respectively).
|
28639889 |
2017 |
|
Malignant tumor of cervix
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thus, WWOX may be considered as a novel important genetic marker in cervical cancer and the association between the altered expression of FHIT and WWOX may be a critical event in the progression of this neoplasia.
|
19700237 |
2010 |
|
Malignant tumor of cervix
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Therefore, we made an attempt to find out point mutation of FHIT gene in HPV mediated cervical cancer in Indian women.
|
19730990 |
2010 |
|
Malignant tumor of cervix
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Effect of aberrant promoter methylation of FHIT and RASSF1A genes on susceptibility to cervical cancer in a North Indian population.
|
18608185 |
2008 |
|
Malignant tumor of cervix
|
0.100 |
Biomarker
|
disease |
BEFREE |
The purpose of this study was to determine the effect of the FHIT gene on tumorigenesis of cervical cancer.
|
16865265 |
2006 |
|
Malignant tumor of cervix
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The effect of codon 98 of the FHIT gene on cervical cancer in Korean women.
|
14675322 |
2004 |
|
Malignant tumor of cervix
|
0.100 |
Biomarker
|
disease |
BEFREE |
We analysed the expression of the fragile histidine triad (FHIT) gene in cervical cancer to evaluate its clinical relevance in relation to human papillomavirus (HPV) infection.
|
12698186 |
2003 |
|
Malignant tumor of cervix
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study we investigated FHIT (Fragile Histidine Triad) protein alterations in cervical carcinomas to assess the relation of this gene with cervical cancer.
|
12657123 |
2003 |
|
Malignant tumor of cervix
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings suggest an association between HPV infection and FHIT gene abnormalities raising the possibility of a mechanistic role for the FHIT gene as a cofactor with HPV in triggering the development of cervical cancer.
|
12144820 |
2002 |
|
Malignant tumor of cervix
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
FRA3B is the most frequently expressed common fragile site localized within human chromosomal band 3p14.2, which is frequently deleted in many different cancers, including cervical cancer.
|
12483524 |
2002 |
|
Malignant tumor of cervix
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest essential roles of genes on these 3p loci, particularly the FHIT gene in participating in clonal selection and early development of cervical cancer.
|
11235906 |
2001 |
|
Malignant tumor of cervix
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These findings demonstrate that truncated FHIT transcripts are commonly detected in both normal and tumor tissues, and suggest that these altered transcripts are not causally related to tumorigenesis in cervical cancer.
|
11498789 |
2001 |
|
Malignant tumor of cervix
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The candidate tumor suppressor gene FHIT has been mapped to 3p14.2, and previous studies have demonstrated reduced or aberrant FHIT transcripts and reduced or absent Fhit protein expression in a large percentage of cervical cancer-derived cell lines and primary cervical carcinomas.
|
10999736 |
2000 |
|
Malignant tumor of cervix
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The finding of a statistically significant relationship between FHIT gene LOH and oncogenic HPV infection suggests a link between the integration of viral DNA and subsequent gene deletion in the progression of cervical cancer.
|
11113868 |
2000 |
|
Malignant tumor of cervix
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our data indicate that alteration of the FHIT gene is an important genetic event associated with cervical cancer and oncogenic
|
9537577 |
1998 |