|
leukemia
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Preclinical assessment of FHIT gene replacement therapy in human leukemia using a chimeric adenovirus, Ad5/F35.
|
16740775 |
2006 |
|
leukemia
|
0.090 |
Biomarker
|
disease |
LHGDN |
Infection efficiency of Ad5/F35-FHIT and Ad5/F35-GFP viruses was tested in leukemia cell lines that lacked FHIT expression, and biological effects of successful infection were assessed.
|
16740775 |
2006 |
|
leukemia
|
0.090 |
PosttranslationalModification
|
disease |
LHGDN |
To test whether aberrant methylation of the FHIT gene may play a role in pediatric leukemia, we assessed the FHIT methylation status of 10 leukemia cell lines and 190 incident population-based cases of childhood acute lymphocytic and myeloid leukemias using methylation-specific PCR.
|
15026336 |
2004 |
|
leukemia
|
0.090 |
PosttranslationalModification
|
disease |
BEFREE |
Hypermethylation of the 5' CpG island of the FHIT gene is associated with hyperdiploid and translocation-negative subtypes of pediatric leukemia.
|
15026336 |
2004 |
|
leukemia
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Our results suggested that patterns III and IV of FHIT transcripts might be associated with the development of a subset of leukaemia, while pattern II which has so far been reported as an aberrant transcript in varieties of malignant tumours might not be associated with leukaemogenesis.
|
10362136 |
1999 |
|
leukemia
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
The high frequency of loss of Fhit expression in ALLs suggests that inactivating alterations at the FHIT locus contribute to development of the leukemias.
|
10499611 |
1999 |
|
leukemia
|
0.090 |
Biomarker
|
disease |
BEFREE |
Our data indicate that whilst aberrant FHIT mRNA transcripts are seen both in normal and malignant cells, lack of FHIT protein is restricted to leukaemia.
|
9926922 |
1999 |
|
leukemia
|
0.090 |
Biomarker
|
disease |
BEFREE |
These findings suggest FHIT gene involvement in the transformation of hematopoietic stem cells to leukemia.
|
9730598 |
1998 |
|
leukemia
|
0.090 |
Biomarker
|
disease |
BEFREE |
Fluorescence in situ hybridization analysis using probes covering exons 5 and 8 revealed no difference in the signal patterns between leukemia and normal cells, showing one or two signal doublets in more than 90% of nuclei, and indicated that gross segments of the FHIT gene were not homozygously deleted in these cases.
|
9823330 |
1998 |
|
leukemia
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Decreased or altered expression of the FHIT gene in human leukemias.
|
9170214 |
1997 |
|
leukemia
|
0.090 |
Biomarker
|
disease |
BEFREE |
To determine the role of the FHIT gene in leukaemia, bone marrow or peripheral blood from 62 acute myeloid leukaemia patients and five haemopoietic cell lines (HL60, U937, Raji, KC-1, K562) were analysed by reverse transcription of the FHIT mRNA followed by PCR amplification and sequencing of the products.
|
9401074 |
1997 |