|
Noonan Syndrome
|
0.560 |
GeneticVariation
|
disease |
BEFREE |
Here, we report a patient with a severe Noonan syndrome phenotype associated with a germline Q71R MRAS variant, which represents a recurrent substitution in RAS homologs in various cancers.
|
31173466 |
2019 |
|
Noonan Syndrome
|
0.560 |
GeneticVariation
|
disease |
BEFREE |
p.Gly23Val-MRAS is both necessary and sufficient to elicit a cardiac hypertrophy phenotype in iPSC-CMs that includes increased cell size, changes in cardiac gene expression, and abnormal calcium handling-providing further evidence to establish the monogenetic pathogenicity of p.Gly23Val-MRAS in NS with cardiac hypertrophy.
|
31638832 |
2019 |
|
Noonan Syndrome
|
0.560 |
GeneticVariation
|
disease |
BEFREE |
A ternary complex comprised of SHOC2, MRAS, and PP1 (SHOC2 complex) functions as a RAF S259 holophosphatase and gain-of-function mutations in SHOC2, MRAS, and PP1 that promote complex formation are found in Noonan syndrome.
|
31213532 |
2019 |
|
Noonan Syndrome
|
0.560 |
GeneticVariation
|
disease |
BEFREE |
Activating mutations in MRAS (as well as SHOC2 and PP1) do occur in the RASopathy Noonan syndrome, underscoring a key role for MRAS within the RAS-ERK pathway.
|
29311130 |
2018 |
|
Noonan Syndrome
|
0.560 |
AlteredExpression
|
disease |
BEFREE |
SHOC2-MRAS-PP1 complex positively regulates RAF activity and contributes to Noonan syndrome pathogenesis.
|
30348783 |
2018 |
|
Noonan Syndrome
|
0.560 |
Biomarker
|
disease |
BEFREE |
MRAS has only recently been related to NS based on the observation of two unrelated affected individuals with de novo variants involving the same codons here found mutated.
|
31108500 |
2019 |
|
Coronary Artery Disease
|
0.450 |
GeneticVariation
|
disease |
BEFREE |
From the above results, the MRAS gene loci might have a minor effect in conferring susceptibility to CAD in Chinese population.
|
25800439 |
2015 |
|
Coronary Artery Disease
|
0.450 |
GeneticVariation
|
disease |
BEFREE |
We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 x 10(-7); OR = 1.08, 95% CI = 1.05-1.11).
|
19198612 |
2009 |
|
Coronary Artery Disease
|
0.450 |
GeneticVariation
|
disease |
BEFREE |
In a preliminary study in heterozygous familial hypercholesterolaemia, we identified a locus linking the early onset of coronary artery disease (CAD) to chromosome 3q.22 and elected to sequence the MRAS gene using the MegaBACE DNA analysis system.
|
23738802 |
2013 |
|
Coronary Artery Disease
|
0.450 |
GeneticVariation
|
disease |
BEFREE |
Aim was to estimate the genotypic distribution and risk allele frequencies of 13 Coronary Artery Disease (CAD) risk Single Nucleotide Polymorphisms in loci identified by the CARDIoGRAMplusC4D consortium namely MIA3 rs17465637; 9p21 rs10757274; CXCL12 rs1746048; APOA5 rs662799; APOB rs1042031; LPA rs3798220; LPA 10455872; MRAS rs9818870; LPL rs328; SORT1 rs646776; PCSK9 rs11591147; APOE rs429358; APOE rs7412 in Pakistani PCAD patients and controls.
|
28705542 |
2019 |
|
Coronary Artery Disease
|
0.450 |
GeneticVariation
|
disease |
BEFREE |
In the current study, locus C12orf43/rs2258287 was found to be associated with the risk of CAD in the studied Pakistani cohort (OR 0.18; CI 0.08-0.37; p = 0.0001) while no association was observed for MRAS/rs9818870 (OR 1.34; CI 0.65-2.76; p = 0.42).
|
27263109 |
2016 |
|
Cardiovascular Diseases
|
0.110 |
Biomarker
|
group |
BEFREE |
Previous studies have indicated that muscle RAS oncogene homolog (MRAS) gene played an important role in cardiovascular diseases.
|
31770223 |
2019 |
|
Malignant Neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
There were eight nonsynonymous mutations (mutation frequency, 17%), showing that MRAS is recurrently mutated in Type IV.
|
27891760 |
2017 |
|
Malignant Neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
MRAS mutations rarely occur in cancer but deregulated expression may play a role in tumorigenesis in some settings.
|
29311130 |
2018 |
|
Myocardial Infarction
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
To analyze if MRAS polymorphism is associated with acute coronary syndrome (ACS) risk in a Czech population and with mortality in male patients after myocardial infarction.
|
29264877 |
2017 |
|
Myocardial Infarction
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Additionally, there is evidence for concordance of SNP associations with both CAC and MI at a number of other loci, including 3q22 (MRAS gene), 13q34 (COL4A1/COL4A2 genes), and 1p13 (SORT1 gene).
|
22144573 |
2011 |
|
Carcinogenesis
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
Our results suggest that MRAS mutation and IGF1R amplification could drive tumorigenesis of Type IV and could be new therapeutic targets.
|
27891760 |
2017 |
|
Carcinogenesis
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
MRAS mutations rarely occur in cancer but deregulated expression may play a role in tumorigenesis in some settings.
|
29311130 |
2018 |
|
Hypertrophic Cardiomyopathy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Activating MRAS mutations cause Noonan syndrome associated with hypertrophic cardiomyopathy.
|
31108500 |
2019 |
|
Colorectal Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
There are several plausible candidate genes for CRC susceptibility within the aforementioned linkage regions including PTCH1, XPA and TGFBR1 in 9q22-31, and EPHB1 and MRAS in 3q21-q24.
|
21811255 |
2011 |
|
Diabetes
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Data from the present study have not proved any significant association of the MRAS and HNF1A genetic polymorphisms with diabetes and diabetic nephropathy in a cohort of Czech population.
|
22849862 |
2012 |
|
Diabetes Mellitus
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Data from the present study have not proved any significant association of the MRAS and HNF1A genetic polymorphisms with diabetes and diabetic nephropathy in a cohort of Czech population.
|
22849862 |
2012 |
|
Diabetic Nephropathy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Data from the present study have not proved any significant association of the MRAS and HNF1A genetic polymorphisms with diabetes and diabetic nephropathy in a cohort of Czech population.
|
22849862 |
2012 |
|
Malignant neoplasm of stomach
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Muscle RAS oncogene homolog (MRAS) recurrent mutation in Borrmann type IV gastric cancer.
|
27891760 |
2017 |
|
Multiple Myeloma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A very high incidence (83%) of t(11;14)(q13;q32) was detected in the IgM (7 of 8), IgE (2 of 2), and NS (11 of 14) MM cases, but not in the IgD cases (2 of 9).
|
12393502 |
2003 |