|
Hypertrophic Cardiomyopathy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Activating MRAS mutations cause Noonan syndrome associated with hypertrophic cardiomyopathy.
|
31108500 |
2019 |
|
Temporomandibular Joint Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Genome-wide association reveals contribution of MRAS to painful temporomandibular disorder in males.
|
30431558 |
2019 |
|
Chronic pain
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Genetic and behavioral evidence support a novel mechanism by which genetically determined MRAS expression moderates the resiliency to chronic pain.
|
30431558 |
2019 |
|
Ischemic stroke
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In relation to lipid profile, rs40593, rs751357, rs6782181 were associated with increased total cholesterol (TC) levels.Summarily, this study suggested that MRAS rs40593 may contribute to the increased risk of area of cerebral infarction of IS in Han population. rs40593, rs751357, and rs6782181 were associated with higher serum TC levels.
|
31770223 |
2019 |
|
Hypertrophic obstructive cardiomyopathy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Activating MRAS mutations cause Noonan syndrome associated with hypertrophic cardiomyopathy.
|
31108500 |
2019 |
|
Primary malignant neoplasm
|
0.010 |
GeneticVariation
|
group |
BEFREE |
MRAS mutations rarely occur in cancer but deregulated expression may play a role in tumorigenesis in some settings.
|
29311130 |
2018 |
|
Malignant neoplasm of stomach
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Muscle RAS oncogene homolog (MRAS) recurrent mutation in Borrmann type IV gastric cancer.
|
27891760 |
2017 |
|
Stomach Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Muscle RAS oncogene homolog (MRAS) recurrent mutation in Borrmann type IV gastric cancer.
|
27891760 |
2017 |
|
Acute Chest Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To analyze if MRAS polymorphism is associated with acute coronary syndrome (ACS) risk in a Czech population and with mortality in male patients after myocardial infarction.
|
29264877 |
2017 |
|
Acute Coronary Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To analyze if MRAS polymorphism is associated with acute coronary syndrome (ACS) risk in a Czech population and with mortality in male patients after myocardial infarction.
|
29264877 |
2017 |
|
Nasopharyngeal carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, RPeL43 is shown to bind with MRAS and EIF2S1 proteins in a NPC cell line (HK1).
|
28018022 |
2016 |
|
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Here we show that SHOC2 and MRAS form a complex with SCRIB, a polarity protein with tumor suppressor properties.
|
24211266 |
2013 |
|
Dyslipidemias
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Our results demonstrate that the genomic locus for the MRAS gene confers risk for CAD, obesity and dyslipidaemia and point to the possible involvement of other genes or regulatory elements at this locus, rather than changes in the M-Ras protein function, in these events.
|
23738802 |
2013 |
|
Familial hypercholesterolemia - heterozygous
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In a preliminary study in heterozygous familial hypercholesterolaemia, we identified a locus linking the early onset of coronary artery disease (CAD) to chromosome 3q.22 and elected to sequence the MRAS gene using the MegaBACE DNA analysis system.
|
23738802 |
2013 |
|
Diabetes
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Data from the present study have not proved any significant association of the MRAS and HNF1A genetic polymorphisms with diabetes and diabetic nephropathy in a cohort of Czech population.
|
22849862 |
2012 |
|
Diabetes Mellitus
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Data from the present study have not proved any significant association of the MRAS and HNF1A genetic polymorphisms with diabetes and diabetic nephropathy in a cohort of Czech population.
|
22849862 |
2012 |
|
Diabetic Nephropathy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Data from the present study have not proved any significant association of the MRAS and HNF1A genetic polymorphisms with diabetes and diabetic nephropathy in a cohort of Czech population.
|
22849862 |
2012 |
|
Colorectal Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
There are several plausible candidate genes for CRC susceptibility within the aforementioned linkage regions including PTCH1, XPA and TGFBR1 in 9q22-31, and EPHB1 and MRAS in 3q21-q24.
|
21811255 |
2011 |
|
Multiple Myeloma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A very high incidence (83%) of t(11;14)(q13;q32) was detected in the IgM (7 of 8), IgE (2 of 2), and NS (11 of 14) MM cases, but not in the IgD cases (2 of 9).
|
12393502 |
2003 |
|
Malignant Neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
MRAS mutations rarely occur in cancer but deregulated expression may play a role in tumorigenesis in some settings.
|
29311130 |
2018 |
|
Carcinogenesis
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
MRAS mutations rarely occur in cancer but deregulated expression may play a role in tumorigenesis in some settings.
|
29311130 |
2018 |
|
Malignant Neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
There were eight nonsynonymous mutations (mutation frequency, 17%), showing that MRAS is recurrently mutated in Type IV.
|
27891760 |
2017 |
|
Myocardial Infarction
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
To analyze if MRAS polymorphism is associated with acute coronary syndrome (ACS) risk in a Czech population and with mortality in male patients after myocardial infarction.
|
29264877 |
2017 |
|
Carcinogenesis
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
Our results suggest that MRAS mutation and IGF1R amplification could drive tumorigenesis of Type IV and could be new therapeutic targets.
|
27891760 |
2017 |
|
Myocardial Infarction
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Additionally, there is evidence for concordance of SNP associations with both CAC and MI at a number of other loci, including 3q22 (MRAS gene), 13q34 (COL4A1/COL4A2 genes), and 1p13 (SORT1 gene).
|
22144573 |
2011 |