ATF5, activating transcription factor 5, 22809

N. diseases: 41; N. variants: 0
Disease: Malignant Glioma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma 		0.040 AlteredExpression disease BEFREE Our studies reported that an anti-apoptotic factor, activating transcription factor 5 (ATF5), is highly expressed in malignant glioma specimens and cell lines. 28595907 2017
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma 		0.040 Biomarker disease BEFREE Thus, we first prepare a construct encoding a human functional DTR driven by the promoter of mouse Atf5, a gene essential for the survival of malignant glioma. 25030919 2014
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma 		0.040 Biomarker disease BEFREE However, it was unknown whether interference with ATF5 function can prevent or promote regression/eradication of malignant gliomas in vivo. 21725368 2012
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma 		0.040 Biomarker disease BEFREE Our results demonstrate that ATF5 is essential in malignant glioma genesis and reveal that the ATF5-mediated survival pathway described here provides potential therapeutic targets for treatment of malignant glioma. 20495567 2010