AAK1, AP2 associated kinase 1, 22848

N. diseases: 16; N. variants: 4
Disease: Neuralgia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.030 Biomarker phenotype BEFREE Clinical trials evaluating inhibitors of AAK1 (neuropathic pain) and SGLT1 (diabetes) are underway. 31064765 2019
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.030 Biomarker phenotype BEFREE We have demonstrated that AAK1 inhibitors are efficacious in rodent models of neuropathic pain (Kostich et al., 2016). 28315351 2017
CUI: C0027796
Disease: Neuralgia
Neuralgia 		0.030 Biomarker phenotype BEFREE Hence, AAK1 inhibitors are a novel therapeutic approach to neuropathic pain with activity in animal models that is mechanistically linked (behaviorally and electrophysiologically) to α2 adrenergic signaling, a pathway known to be antinociceptive in humans. 27411717 2016