|
Schizophrenia
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
We examined the hypothesis that NTNG1 allelic variation contributes to the risk for schizophrenia.
|
25325217 |
2014 |
|
Schizophrenia
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to investigate the potential association of netrin G1 (NTNG1) rs628117 and brain-derived neurotrophic factor (BDNF) Val66Met (rs6265) genetic polymorphisms with susceptibility to schizophrenia.
|
21641949 |
2011 |
|
Schizophrenia
|
0.370 |
Biomarker
|
disease |
BEFREE |
Using quantitative polymerase chain reaction, we quantified transcripts for VGluT1, netrin-G1 (isoforms G1c, G1d, and G1f), and netrin-G2 in the anterior cingulate cortex from subjects with bipolar disorder (n = 34), schizophrenia (n = 35), and healthy control subjects (n = 35).
|
20079890 |
2010 |
|
Schizophrenia
|
0.370 |
AlteredExpression
|
disease |
BEFREE |
For NTNG1, the G1c isoform was reduced in bipolar disorder and with a similar trend in schizophrenia; expression of four other NTNG1 isoforms was unchanged.
|
17507910 |
2008 |
|
Schizophrenia
|
0.370 |
Biomarker
|
disease |
BEFREE |
These findings support that the NTNG1 gene is associated with schizophrenia in the Japanese.
|
18384956 |
2008 |
|
Schizophrenia
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
Specific haplotypes encompassing alternatively spliced exons of NTNG1 were associated with schizophrenia, and concordantly, messenger ribonucleic acid isoform expression was significantly different between schizophrenic and control brains.
|
15705354 |
2005 |
|
Colorectal Carcinoma
|
0.320 |
Biomarker
|
disease |
BEFREE |
Our previous studies have found that semaphorin-3F (SEMA3F), an axon guidance molecule in the development of central nervous system, inhibited the growth and metastasis of colorectal cancer (CRC).
|
25529012 |
2015 |
|
Colorectal Carcinoma
|
0.320 |
Biomarker
|
disease |
BEFREE |
SLIT2 axon guidance molecule is frequently inactivated in colorectal cancer and suppresses growth of colorectal carcinoma cells.
|
12615722 |
2003 |
|
Bipolar Disorder
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
Decreased mRNA expression of netrin-G1 and netrin-G2 in the temporal lobe in schizophrenia and bipolar disorder.
|
17507910 |
2008 |
|
Rett Syndrome, Atypical
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
This study tested a sample of 91 female patients with a clinically heterogeneous phenotype ranging from encephalopathy with epilepsy to atypical Rett syndrome without epilepsy for mutations in the Netrin G1 gene, to evaluate its involvement in this condition.
|
17903671 |
2007 |
|
Intellectual Disability
|
0.110 |
GeneticVariation
|
group |
BEFREE |
Mutations of the cyclin-dependent kinase-like 5 (CDKL5) and netrin-G1 (NTNG1) genes cause a severe neurodevelopmental disorder with clinical features that are closely related to Rett syndrome, including intellectual disability, early-onset intractable epilepsy and autism.
|
22922712 |
2012 |
|
Rett Syndrome
|
0.040 |
Biomarker
|
disease |
BEFREE |
While NTNG1 has previously been linked to a Rett syndrome (RTT)-like phenotype, this is the first description of a RTT-like phenotype caused by NTNG2 mutation.
|
31692205 |
2019 |
|
Rett Syndrome
|
0.040 |
Biomarker
|
disease |
BEFREE |
Mutations of the cyclin-dependent kinase-like 5 (CDKL5) and netrin-G1 (NTNG1) genes cause a severe neurodevelopmental disorder with clinical features that are closely related to Rett syndrome, including intellectual disability, early-onset intractable epilepsy and autism.
|
22922712 |
2012 |
|
Rett Syndrome
|
0.040 |
Biomarker
|
disease |
BEFREE |
Mutations in the NTNG1 gene appear to be a rare cause of RTT but NTNG1 function demands further investigation in relation to the central nervous system pathophysiology of the disorder.
|
16502428 |
2006 |
|
Rett Syndrome
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that the central nervous system is sensitive to NTNG1 expression levels and that NTNG1 is a novel candidate disease gene for RTT.
|
15870826 |
2005 |
|
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Annexin A2 (ANXA2) regulates secretion of SEMA3D, an axon guidance molecule, which binds and activates the receptor PLXND1 to promote PDA invasion and metastasis.
|
31163177 |
2019 |
|
Neoplasms
|
0.030 |
GeneticVariation
|
group |
BEFREE |
Hyper-methylated CpG loci included the known the tumor suppressor gene RET (p = 5.72 x 10-10), as well as loci in differentially methylated regions for GSG1L, MIR4493, NTNG1, MCIDAS, ZNF568, and RERG.
|
28257124 |
2017 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Axon guidance molecule semaphorin3A is a novel tumor suppressor in head and neck squamous cell carcinoma.
|
26755661 |
2016 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Netrin-1, an axon guidance molecule, has been found in several tumors in adults.
|
27651158 |
2016 |
|
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Our previous studies have found that semaphorin-3F (SEMA3F), an axon guidance molecule in the development of central nervous system, inhibited the growth and metastasis of colorectal cancer (CRC).
|
25529012 |
2015 |
|
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Of interest, we found that an axon guidance molecule, Semaphorin 3F (SEMA3F), is among the top 1% underexpressed genes in HNSCC, and that genomic loss of SEMA3F correlates with increased metastasis and decreased survival.
|
25952650 |
2015 |
|
Neuropathy
|
0.010 |
Biomarker
|
group |
BEFREE |
Gene expression of netrin 1 (p < 0.05 in proximal skin), DCC (p < 0.001 in distal skin), NEO1 (p < 0.05 in distal skin), netrin G1 (p < 0.05 in proximal and p < 0.01 in distal skin), and netrin G2 (p < 0.001 in distal skin) was lower in skin biopsies of patients with neuropathy compared to healthy controls.
|
31392393 |
2019 |
|
Mirror movements disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Recently identified mutations of the axon guidance molecule receptor gene, DCC, present an opportunity to investigate, in living human brain, mechanisms affecting neural connectivity and the basis of mirror movements, involuntary contralateral responses that mirror voluntary unilateral actions.
|
30666715 |
2019 |
|
Inherited neuropathies
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Other candidate genes identified include SLIT3 which encodes an axon guidance molecule and in three families, phenolyzer prioritized genes that are associated with hereditary neuropathies (family A, KARS, family B, KIF5A and family F, NTRK1).
|
31404076 |
2019 |
|
Cerebrovascular accident
|
0.010 |
Biomarker
|
group |
BEFREE |
As a secreted axon guidance molecule, Netrin-1 has been documented to be a neuroprotective factor, which can reduce infarct volume, promote angiogenesis and anti-apoptosis after stroke in rodents.
|
29487502 |
2018 |