Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Selective inhibition of FKBP51 has emerged as possible novel treatment for diseases like major depressive disorder, obesity, chronic pain, and certain cancers.
|
31800244 |
2020 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We investigated the effects of the rs1360780 polymorphism of the hypothalamic-pituitary-axis related gene FKBP5 in combination with early life stress (ELA) on the structure of hippocampal subfields in MDD.
|
30986730 |
2019 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This is the first study to investigate interactions between FKBP5 variants and a range of environmental stressors in adolescents with a clinical diagnosis of MD.
|
30953930 |
2019 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to review and conduct a meta-analysis on the results from published studies examining interaction between FKBP5 gene variants and early-life stress and their associations with stress-related disorders such as major depression and PTSD.
|
28850857 |
2018 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
There is strong evidence suggesting altered regulation of steroid receptor hormones by chaperones, particularly the 51 kDa FK506-binding protein (FKBP51), may work with environmental factors to increase susceptibility to various psychiatric illnesses including post-traumatic stress disorder (PTSD), major depressive disorder (MDD), and anxiety.
|
30585227 |
2018 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In all participants, lower FKBP5 intron methylation levels were associated with reduced gray matter concentration in the inferior frontal orbital gyrus bilaterally (Wald chi-square=11.93, p<sub>FDR</sub><0.01) and, in MDD, with its bilaterally higher activation during valence recognition (Wald chi-square=5.58, p=0.02).
|
29182159 |
2018 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our goal was to study the role of FKBP5 genetic variants in HPA axis negative feedback regulation as a possible risk factor for different mental disorders such as MDD and OCD, while controlling for childhood trauma, anxiety and depressive symptoms.
|
30107269 |
2018 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Three samples with major depressive disorder (total=671) were genotyped for 44 SNPs in 8 candidate genes (CACNA1C, CACNB2, ANK3, GRM7, TCF4, ITIH3, SYNE1, FKBP5).
|
28989100 |
2018 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Single nucleotide polymorphisms (SNPs) in the FKBP5 gene are associated with altered hypothalamus-pituitary-adrenal (HPA) axis function, changes in the structure and function of several cognitive brain areas, and increased susceptibility to post-traumatic stress disorder, major depression, bipolar disorder and suicidal events.
|
28002634 |
2017 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Gene-wide significant results were found for dexamethasone suppression (CYP11A1, CYP17A1, POU1F1, AKR1D1), hippocampal volume (CYP17A1, CYP11A1, HSD3B2, PROP1, AVPRA1, SRD5A1), amygdala volume (POMC, CRH, HSD3B2), and lifetime MDD diagnosis (FKBP5 and CRH), all permutation p-values<0.05.
|
28589964 |
2017 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that the FKBP5 gene and its epigenetic changes could have influence on morphologic changes of several brain regions involved in emotion regulation, and that this process may be associated with the development of MDD.
|
28198448 |
2017 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In contrast, NR3C2, FKBP5 and CRHR1 polymorphisms were not significantly associated with MDD.
|
27549215 |
2017 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to analyze the expression of 3 genes involved in the regulation of HPA axis: GR, HSP90 and FKBP5, in patients with major depressive disorder (MDD) before antidepressant treatment and after 8 weeks of pharmacotherapy.
|
29432501 |
2017 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
A total of 298 major depressive disorder (MDD) inpatients from the multicentred German project and the Zurich Algorithm Project were genotyped for their FKBP5 status.
|
26645208 |
2016 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
We tested the relationship between genotype, gene expression and suicidal behavior and major depressive disorder (MDD) in live subjects and postmortem samples for three genes, associated with the hypothalamic-pituitary-adrenal axis, suicidal behavior, and MDD; FK506-binding protein 5 (FKBP5), Spindle and kinetochore-associated protein 2 (SKA2), and Glucocorticoid Receptor (NR3C1).
|
27030168 |
2016 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Future research should also investigate possible gender- and ethnicity-specific differences in the association between FKBP5 and MDD.
|
27601205 |
2016 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The FK506-binding protein 51 (FKBP51, encoded by the FKBP5 gene) is an established risk factor for stress-related psychiatric disorders such as major depression.
|
25436518 |
2015 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
The FK506-binding protein 51 (FKBP51, encoded by the FKBP5 gene) is an established risk factor for stress-related psychiatric disorders such as major depression.
|
25436518 |
2015 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Therefore, the results suggest that accumulation of the GR in cytoplasm is related to the elevation of FKBP5, adding one more step in understanding altered GR signalling in lymphocytes, and potentially brain tissue, of MDD patients.
|
25355489 |
2015 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Therefore, the results suggest that accumulation of the GR in cytoplasm is related to the elevation of FKBP5, adding one more step in understanding altered GR signalling in lymphocytes, and potentially brain tissue, of MDD patients.
|
25355489 |
2015 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
We have observed an association between five FKBP5 polymorphisms (rs1360780, rs9470080, rs4713916, rs9296158 and rs9394309) and major depressive disorder (p=0.011; p=0.007, p=0.038; p=0.030; p=0.018, respectively), but not bipolar disorder.
|
24856550 |
2014 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We have observed an association between five FKBP5 polymorphisms (rs1360780, rs9470080, rs4713916, rs9296158 and rs9394309) and major depressive disorder (p=0.011; p=0.007, p=0.038; p=0.030; p=0.018, respectively), but not bipolar disorder.
|
24856550 |
2014 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
In the present study, we investigated whether the FKBP5 polymorphism rs1360780 and lifetime history of major depression are associated with DNA methylation and FKBP5 gene expression after psychosocial stress.
|
25522420 |
2014 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we investigated whether the FKBP5 polymorphism rs1360780 and lifetime history of major depression are associated with DNA methylation and FKBP5 gene expression after psychosocial stress.
|
25522420 |
2014 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Genetic variations in the co-chaperone FK506-binding protein 51, FKBP5, which modulates the function of glucocorticoid receptors, have been associated with an increased risk for the development of posttraumatic stress disorder, but data regarding its role in MDD are controversial.
|
23861224 |
2013 |