|
Drug abuse
|
0.100 |
GeneticVariation
|
group |
BEFREE |
BPD is associated with FKBP5 polymorphisms and several types of childhood abuse may modulate the effect between FKBP5 SNPs and this disorder.
|
30711865 |
2019 |
|
Drug abuse
|
0.100 |
GeneticVariation
|
group |
BEFREE |
This model was simplified using backward elimination, retaining six predictors: smoking status, psychopathy (interpersonal manipulation and callous affect), childhood trauma (physical abuse and neglect), and the FKBP5_13 gene (rs1360780).
|
29867390 |
2018 |
|
Drug abuse
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Anxious depressed patients showed an enhanced GR-induced FKBP5 mRNA expression (F = 5.128; p = 0.03) and reduced cortisol levels, partly dependent on sexual abuse (F = 7.730; p = 0.006).
|
30086534 |
2018 |
|
Drug abuse
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Findings suggest that childhood abuse is associated with decreased functional connectivity in fronto-parietal attention networks and that the FKBP5 genotype moderates neurobiological vulnerability to abuse.
|
29190830 |
2017 |
|
Drug abuse
|
0.100 |
GeneticVariation
|
group |
BEFREE |
They further indicate that FKBP5 polymorphisms and childhood abuse may contribute to vulnerability for PTSD symptoms and may be most strongly associated with trauma-related hyperarousal symptoms that comprise this phenotype.
|
27078785 |
2016 |
|
Drug abuse
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Two FKBP5 alleles (rs3798347-T and rs10947563-A) were more frequent in BPD subjects with history of physical abuse and emotional neglect and two CRHR2 variants (rs4722999-C and rs12701020-C) in BPD subjects with sexual and physical abuse.
|
26182893 |
2016 |
|
Drug abuse
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In contrast to the findings at bin 3/site 6, offspring methylation at bin 2/sites 3 to 5 was associated with childhood physical and sexual abuse in interaction with an FKBP5 risk allele previously associated with vulnerability to psychological consequences of childhood adversity.
|
26410355 |
2016 |
|
Drug abuse
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We observed a significant influence of the FKBP5 high-expression diplotype on both a lifetime history of aggressive behavior (BGHA) (P = .012) and violent behavior in jail (P = .025) but only in individuals exposed to childhood trauma, in particular to physical abuse.
|
22213790 |
2012 |
|
Drug abuse
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Common polymorphisms in the human gene for FK506 binding protein 5 (FKBP5), which is involved in transcriptional regulation of the hypothalamic-pituitary-adrenal (HPA) axis, have been shown to interact with childhood abuse and trauma to predict stress-related psychopathology.
|
22979952 |
2012 |
|
Drug abuse
|
0.100 |
GeneticVariation
|
group |
BEFREE |
This study revealed interactions between physical abuse and rs1360780 of the FKBP5 gene, confirming its role in the individual susceptibility to depression.
|
21654733 |
2011 |
|
Drug abuse
|
0.100 |
Biomarker
|
group |
BEFREE |
This study provides further evidence of a gene x environment effect of FKBP5 and childhood abuse on the risk for PTSD in AAs.
|
20393453 |
2010 |
|
Drug abuse
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults.
|
18349090 |
2008 |