|
Stress, Psychological
|
0.100 |
Biomarker
|
disease |
BEFREE |
We investigated the effects of diagnosis, FKBP5 allelic status and their interaction as predictors of hippocampal subfield volumes as well as the effect of ELA and its interaction with FKBP5.
|
30986730 |
2019 |
|
Stress, Psychological
|
0.100 |
Biomarker
|
disease |
BEFREE |
Early Life Stress and High FKBP5 Interact to Increase Anxiety-Like Symptoms through Altered AKT Signaling in the Dorsal Hippocampus.
|
31167373 |
2019 |
|
Stress, Psychological
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to review and conduct a meta-analysis on the results from published studies examining interaction between FKBP5 gene variants and early-life stress and their associations with stress-related disorders such as major depression and PTSD.
|
28850857 |
2018 |
|
Stress, Psychological
|
0.100 |
Biomarker
|
disease |
BEFREE |
Almost consistently, these studies revealed that polymorphisms in COMT, BDNF, and FKBP5 genes might interact with early life stress and cannabis abuse or dependence, influencing various outcomes of schizophrenia spectrum disorders and BD.
|
28822116 |
2018 |
|
Stress, Psychological
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The present findings suggest that Fkbp5 expression in mesocorticolimbic dopaminergic regions associates with early life stress-mediated sensitivity to alcohol drinking and that FKBP5 genotype interacts with parent-child relationship to influence alcohol drinking.
|
27709495 |
2017 |
|
Stress, Psychological
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
In addition, FKBP5 methylation mediated the association between early life stress and inhibition-related prefrontal activity.
|
29162190 |
2017 |
|
Stress, Psychological
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
FKBP5 genotype and early life stress exposure predict neurobehavioral outcomes for preterm infants.
|
28247564 |
2017 |
|
Stress, Psychological
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the current study, we examined interactions between self-reported early life trauma, past-year life stress, past-year trauma, and a single nucleotide polymorphism (rs1360780) in FKBP5 on heavy alcohol consumption in a sample of 1,845 college students from two university settings.
|
27196697 |
2016 |
|
Stress, Psychological
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present study was to investigate the effects of 6 FK506 binding protein 51 (FKBP5) single nucleotide polymorphisms (SNPs) on brain structure using voxel-based morphometry (VBM) and the psychological tests to psychological stress.
|
26982819 |
2016 |
|
Stress, Psychological
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present study examined whether early life stress and genetic profile scores (10 single nucleotide polymorphisms within 4 hypothalamic-pituitary-adrenal axis genes: CRHR1, NR3C2, NR3C1, and FKBP5) predicted individual differences in amygdala functional connectivity in school-age children (9- to 14-year-olds; N = 120).
|
26595470 |
2015 |
|
Stress, Psychological
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to examine whether FKBP5 rs1360780 moderates relations between different forms of life stress/adversity (early institutional rearing and peer victimization) and depressive symptoms in adolescents.
|
25462914 |
2015 |
|
Stress, Psychological
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study tested the hypothesis that genetic profile scores combining variance across 10 single nucleotide polymorphisms from four stress-system genes (CRHR1, NR3C2, NR3C1, and FKBP5) and early life stress would predict increases in cortisol levels during laboratory stressors in 120 preschool-age children (3-5 years old), as well as hippocampal and amygdala volumes assessed with MRI in these same children at school age (7-12 years old).
|
24304824 |
2014 |
|
Stress, Psychological
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
It has been reported that a C/T single nucleotide polymorphism in the intron 2 of FKBP5 gene (rs1360780) affects FKBP5 protein levels and cortisol response to dexamethasone and psychological stress tests.
|
20849924 |
2010 |