Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
However, FKBP5 methylation of these five CpG sites could not be validated as a valuable clinical biomarker for biological long-term effects of childhood maltreatment or lifetime depression.
|
30700816 |
2019 |
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The significant interaction between ELA and the rs1360780 polymorphism in HATA suggests a role of FKBP5 in the pathophysiology of structural alterations in depression.
|
30986730 |
2019 |
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
FKBP5 Gene Expression Predicts Antidepressant Treatment Outcome in Depression.
|
30678080 |
2019 |
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The FK506-binding protein 51 (FKBP51) has emerged as a key regulator of endocrine stress responses in mammals and as a potential therapeutic target for stress-related disorders (depression, post-traumatic stress disorder), metabolic disorders (obesity and diabetes) and chronic pain.
|
30669684 |
2019 |
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Clinical association to FKBP5 rs1360780 in patients with depression.
|
31219960 |
2019 |
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Edaravone presents antidepressant-like activity in corticosterone model of depression in mice with possible role of Fkbp5, Comt, Adora1 and Slc6a15 genes.
|
31344373 |
2019 |
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Childhood adversity showed an interaction with the brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism, serotonin transporter-linked promoter region (5-HTTLPR), and FK506 binding protein 51 (FKBP5) gene rs1360780 in brain morphologic changes in patients with depression and in a non-clinical population.
|
29535036 |
2019 |
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Further, certain microRNAs (miRNAs), such as miR-124a and miR-18a, which could reduce GR protein expression, contribute to affective disorders, while miR-511 as a regulator of FKBP5 is involved in an increased risk of depression.
|
30469088 |
2019 |
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Here, our objective was to assess mRNA levels of GC-related markers (GR, FKBP5, serum glucocorticoid kinase 1 [SGK1]) in patients with depression versus controls and in patient samples after electroconvulsive therapy (ECT).
|
31725056 |
2019 |
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
V.G.F. received honorarium for being a speaker for H. Lundbeck A/S.E.B.B. receives research funding from Böhringer Ingelheim to investigate FKBP5 as a potential drug target for depression.
|
30457060 |
2019 |
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
We also identified a female-specific association between FKBP5 mRNA expression and scores on the Beck Anxiety Inventory (r = 0.37, p = 0.013) and Beck Depression Inventory-II (r = 0.32, p = 0.033).
|
30036794 |
2018 |
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
FKBP5 showed elevated expression levels in participants with vs. without a history of depression (p < 0.001); no significant difference in gene expression levels was observed in relation to childhood maltreatment (p > 0.05).
|
28961425 |
2018 |
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Our results suggest that an increased risk for depression may be transmitted from mother to child during fetal life and that the effect is dependent upon neonatal FKBP5 genotype.
|
28975925 |
2018 |
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
We assessed methylation levels at CpG sites in regions of the serotonin transporter (<i>SLC6A4</i>) previously associated with expression and depression outcomes, as well as the Intron 7 region of the FK506 binding protein 5 (<i>FKBP5</i>) containing known glucocorticoid response elements suggested to regulate this gene.
|
30279666 |
2018 |
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Also, no associations of FKBP5 and MR polymorphisms were found on PTSD and depression outcomes.
|
29879676 |
2018 |
Depressed mood
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
In the model of depression employed here, decreases in MR expression and GR co-chaperone (FKBP51) levels in the hippocampus were also observed, and HFD intensified the prenatal stress-induced changes in MR expression.
|
29524264 |
2018 |
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Targeting the FKBP51/GR/Hsp90 Complex to Identify Functionally Relevant Treatments for Depression and PTSD.
|
29893552 |
2018 |
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
In the context of environmental stress, a functional variant in the glucocorticoid receptor co-chaperone FKBP5 gene has been repeatedly shown to increase risk for psychiatric illness, including depression.
|
27485401 |
2017 |
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Our data reveals alterations of the communication patterns between the hippocampus and the rest of the brain in depression, effects potentially driven by overall familial factors (genes plus shared twin environment) and modified by the FKBP5 gene.
|
26801675 |
2017 |
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Using Cox regression models and cumulative incidence plots, we analyzed the associations between genetic variants in 5-HTTLPR, BDNF, HTR1A, COMT, and FKBP5 and use of antidepressants as well as hospital contact for depression after diagnosis of cancer.
|
28590587 |
2017 |
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
However, none of the SNPs located within AVP, CRH, CRHR1, CRHR2, FKBP5 or NC3C1 were associated with depression.
|
27264499 |
2017 |
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The association between DNA methylation of seven genes, including BDNF, SLC6A4, NR3C1, 5-HTR (1A, 2A, and 3A), FKBP5, MAO-A and OXTR, and depression were reviewed in this study.
|
28645747 |
2017 |
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Studies have shown that FKBP5 genotypes moderate the risk of post-traumatic stress disorder and depression in traumatized adults.
|
26521051 |
2016 |
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The gene that encodes the FK506-binding protein 5 (FKBP5) is regarded as a candidate for investigating how negative life events interact with a genetic predisposition to stress-related disorders, such as depression and anxiety.
|
27448712 |
2016 |
Depressed mood
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Single-Nucleotide Polymorphism of the FKBP5 Gene and Childhood Maltreatment as Predictors of Structural Changes in Brain Areas Involved in Emotional Processing in Depression.
|
26076833 |
2016 |