Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Interaction of several genes with childhood trauma to produce pathological, clinical phenomena in adulthood has been demonstrated, the most important in this respect being the serotonin transporter gene and the FKBP5 gene playing an important role in the pathogenesis of mood disorders.
|
30544098 |
2019 |
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Interactions between FKBP5 gene variants and early-life stress may enhance the risk not only for mood disorder, but also for a number of other behavioral phenotypes.
|
28850857 |
2018 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
FK-506 binding protein 5 (<i>FKBP5</i>) encodes the FKBP51 protein, a heat shock protein 90 kDa (Hsp90) co-chaperone, and is a risk factor for several affective disorders.
|
29203717 |
2018 |
Mood Disorders
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
Effect of Genotype and Maternal Affective Disorder on Intronic Methylation of FK506 Binding Protein 5 in Cord Blood DNA.
|
30619472 |
2018 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Clinical studies suggest a genetic link between FKBP51 and antidepressant response in mood disorders; however, the underlying mechanisms remain elusive.
|
25386878 |
2014 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The FKBP5 gene product modulates glucocorticoid receptor function and has been previously associated with differential hippocampal structure, function, and affect disorder risk.
|
24253961 |
2014 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
PSYGENET |
These FKBP5 SNPs were previously associated with diverse affective disorders and showed functional differences in gene expression and stress response.
|
24845178 |
2014 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
PSYGENET |
Clinical studies suggest a genetic link between FKBP51 and antidepressant response in mood disorders; however, the underlying mechanisms remain elusive.
|
25386878 |
2014 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
These FKBP5 SNPs were previously associated with diverse affective disorders and showed functional differences in gene expression and stress response.
|
24845178 |
2014 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
PSYGENET |
The FKBP5 gene product modulates glucocorticoid receptor function and has been previously associated with differential hippocampal structure, function, and affect disorder risk.
|
24253961 |
2014 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
PSYGENET |
Among these were FKBP5 and WFS1, which have been previously implicated in mood disorders.
|
23945090 |
2013 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The role of FKBP5 in mood disorders: action of FKBP5 on steroid hormone receptors leads to questions about its evolutionary importance.
|
24040820 |
2013 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
PSYGENET |
The role of FKBP5 in mood disorders: action of FKBP5 on steroid hormone receptors leads to questions about its evolutionary importance.
|
24040820 |
2013 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
In human genetic association studies, FKBP51 has repeatedly been associated with emotion processing and numerous stress-related affective disorders.
|
22581765 |
2012 |
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
This lends strong support to the concept emerging from human studies of FKBP5 as important factor governing gene-environment interactions relevant for the etiology of affective disorders.
|
21907973 |
2011 |
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
This meta-analysis demonstrates that treatment response in patients with mood disorders is associated with FKBP5 gene rs4713916 polymorphism, but not rs1360780 and rs3800373.
|
20709156 |
2010 |