KLRK1, killer cell lectin like receptor K1, 22914

N. diseases: 255; N. variants: 2
Disease: Crohn Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.060 Biomarker disease BEFREE This review will describe the receptor and its ligands in intestinal tissues and the clinical potential of blocking NKG2D in Crohn's disease. 28926962 2017
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.060 AlteredExpression disease BEFREE B cells, monocytes, mucosal epithelium, and vascular endothelium expressed NKG2D ligands in inflamed CD intestine. 28684217 2017
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.060 Biomarker disease BEFREE Anti-NKG2D monoclonal antibody (NNC0142-0002) in active Crohn's disease: a randomised controlled trial. 27489241 2017
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.060 AlteredExpression disease BEFREE Increased expression of MICA in intestinal epithelial cells and increased expression of NKG2D in CD4(+) T cells (lamina propria) in patients with CD have also been reported. 25386052 2014
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.060 AlteredExpression disease BEFREE We investigated the Th17 cytokines produced by T cells that express NKG2D in blood and intestinal mucosa samples from patients with CD. 21600899 2011
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.060 AlteredExpression disease LHGDN CD4(+)NKG2D(+) T cells with a Th1 cytokine profile and expressing perforin were increased in the periphery and in the mucosa in CD. 17570210 2007