|
Idiopathic Pulmonary Fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IPF is characterized primarily by excessive deposition of extracellular matrix (ECM) proteins by activated lung fibroblasts and myofibroblasts, resulting in reduced gas exchange and impaired pulmonary function.
|
30130563 |
2019 |
|
Idiopathic Pulmonary Fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition to proteins with well-known functions such as COL1A1, SCGB1A1, TAGLN, PSEN2, TSPAN1, CTSB, AGR2, CSPG2, and SERPINB3, we identified several novel ECM proteins with unknown function deposited in IPF lung tissue including LGALS7, ASPN, HSP90AA1 and HSP90AB1.
|
30774578 |
2019 |
|
Idiopathic Pulmonary Fibrosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Both normal and pathogenic IPF lung fibroblasts express functional IL-17RA and respond to IL-17A stimulation with cell proliferation, generation of extracellular matrix (ECM) proteins, and induction of myofibroblast transdifferentiation.
|
30604628 |
2019 |
|
Idiopathic Pulmonary Fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Idiopathic pulmonary fibrosis (IPF) is a chronic disease characterized by the pathological remodeling of air sacs as a result of excessive accumulation of extracellular matrix (ECM) proteins, but the mechanism governing the robust protein expression is poorly understood.
|
31488543 |
2019 |
|
Idiopathic Pulmonary Fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Idiopathic pulmonary fibrosis (IPF) is characterized by accumulation of extracellular matrix (ECM) proteins and fibroblast proliferation.
|
29053339 |
2018 |
|
Idiopathic Pulmonary Fibrosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our comprehensive analyses of mRNA, miRNA, and matrisome proteomic profiles in IPF and SSc lung fibroblasts revealed robust fibrotic signatures at both the gene and protein expression levels and identified novel fibrogenesis-associated miRNAs whose aberrant downregulation in disease fibroblasts likely contributes to their fibrotic and ECM gene expression.
|
30501089 |
2018 |
|
Idiopathic Pulmonary Fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
LTBP2 staining in IPF lungs was broadly positive in the fibrotic interstitium, mainly as an extracellular matrix (ECM) protein; however, some of the αSMA-positive myofibroblasts were also stained.
|
30006483 |
2018 |
|
Idiopathic Pulmonary Fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the lung, SPARC drives pathological responses in non-small cell lung cancer and idiopathic pulmonary fibrosis by promoting microvascular remodelling and excessive deposition of ECM proteins.
|
27759879 |
2017 |
|
Idiopathic Pulmonary Fibrosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A total of 20 ECM proteins were upregulated and 6 proteins downregulated in IPF.
|
25064447 |
2014 |
|
Idiopathic Pulmonary Fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Several genes involved in retinol metabolism and ECM receptor interaction enable discrimination of vascular remodeling in PH-IPF or PH-COPD.
|
24918967 |
2014 |
|
Idiopathic Pulmonary Fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We determined that genes encoding IPF-associated ECM proteins are targets for miR-29, which was downregulated in fibroblasts grown on IPF-derived ECM, and baseline expression of ECM targets could be restored by overexpression of miR-29.
|
24590289 |
2014 |
|
Idiopathic Pulmonary Fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Idiopathic pulmonary fibrosis (IPF) is a progressive disease characterized by fibroblast proliferation and excess deposition of collagen and other extracellular matrix (ECM) proteins, which lead to distorted lung architecture and function.
|
19966781 |
2009 |
|
Idiopathic Pulmonary Fibrosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Idiopathic pulmonary fibrosis (IPF) is a refractory and lethal interstitial lung disease characterized by alveolar epithelial cells apoptosis, fibroblast proliferation, and ECM protein deposition.
|
18621908 |
2008 |