ATF6, activating transcription factor 6, 22926

N. diseases: 179; N. variants: 30
Disease: Asthma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004096
Disease: Asthma
Asthma 		0.030 AlteredExpression disease BEFREE Quantitative mRNA analysis of airway epithelial brushings from human subjects demonstrated that several ATF6α-related transcripts were significantly upregulated in patients with asthma compared with healthy subjects. 31045581 2019
CUI: C0004096
Disease: Asthma
Asthma 		0.030 Biomarker disease BEFREE In addition, ORMDL3 activates the ATF6α branch of the unfolded protein response which regulates SERCA2b and IL-6, pathways of potential importance to asthma. 28826527 2017
CUI: C0004096
Disease: Asthma
Asthma 		0.030 Biomarker disease BEFREE The ATF6 target gene SERCA2b, implicated in airway remodeling in asthma, was strongly induced in the lungs of hORMDL3(zp3-Cre) mice. 24623133 2014